ATP12A

ATPase, H+/K+ transporting, nongastric, alpha polypeptide
Identifiers
Symbols	ATP12A ; ATP1AL1
External IDs	OMIM: 182360 MGI: 1926943 HomoloGene: 68197 ChEMBL: 2933 GeneCards: ATP12A Gene
EC number	3.6.3.10
Gene ontology Molecular function • sodium:potassium-exchanging ATPase activity • ATP binding • hydrogen:potassium-exchanging ATPase activity • metal ion binding Cellular component • plasma membrane • hydrogen:potassium-exchanging ATPase complex • basolateral plasma membrane • apical plasma membrane Biological process • potassium ion transport • regulation of pH • metabolic process • response to metal ion • response to organic cyclic compound • ion transmembrane transport • sodium ion transmembrane transport • potassium ion homeostasis • transmembrane transport • hydrogen ion transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	479	192113
Ensembl	ENSG00000075673	ENSMUSG00000022229
UniProt	P54707	Q9Z1W8
RefSeq (mRNA)	NM_001185085	NM_138652
RefSeq (protein)	NP_001172014	NP_619593
Location (UCSC)	Chr 13: 24.68 – 24.71 Mb	Chr 14: 56.37 – 56.39 Mb
PubMed search

ATPase, H+/K+ transporting, nongastric, alpha polypeptide (also known as ATP12A) is a protein that in humans is encoded by the ATP12A gene.^[1][2][3]

Function

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H⁺/K⁺ -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H⁺ and K⁺ ions across the plasma membrane. It is also responsible for potassium absorption in various tissues.^[1]

References

1. "Entrez Gene: ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide".
2. Sverdlov VE, Kostina MB, Modyanov NN (March 1996). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase". Genomics 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
3. Yang-Feng TL, Schneider JW, Lindgren V, Shull MM, Benz EJ, Lingrel JB, Francke U (February 1988). "Chromosomal localization of human Na⁺, K⁺-ATPase alpha- and beta-subunit genes". Genomics 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.

Further reading

• Modyanov NN, Petrukhin KE, Sverdlov VE; et al. (1991). "The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase.". FEBS Lett. 278 (1): 91–4. doi:10.1016/0014-5793(91)80091-G. PMID 1847115.
• Yang-Feng TL, Schneider JW, Lindgren V; et al. (1988). "Chromosomal localization of human Na+, K+-ATPase alpha- and beta-subunit genes.". Genomics 2 (2): 128–38. doi:10.1016/0888-7543(88)90094-8. PMID 2842249.
• Shull MM, Lingrel JB (1987). "Multiple genes encode the human Na+,K+-ATPase catalytic subunit.". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4039–43. doi:10.1073/pnas.84.12.4039. PMC 305017. PMID 3035563.
• Sverdlov ED, Monastyrskaya GS, Broude NE; et al. (1987). "The family of human Na+,K+-ATPase genes. No less than five genes and/or pseudogenes related to the alpha-subunit.". FEBS Lett. 217 (2): 275–8. doi:10.1016/0014-5793(87)80677-4. PMID 3036582.
• Grishin AV, Sverdlov VE, Kostina MB, Modyanov NN (1994). "Cloning and characterization of the entire cDNA encoded by ATP1AL1--a member of the human Na,K/H,K-ATPase gene family.". FEBS Lett. 349 (1): 144–50. doi:10.1016/0014-5793(94)00655-5. PMID 8045293.
• Sverdlov VE, Kostina MB, Modyanov NN (1997). "Genomic organization of the human ATP1AL1 gene encoding a ouabain-sensitive H,K-ATPase.". Genomics 32 (3): 317–27. doi:10.1006/geno.1996.0125. PMID 8838794.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Pestov NB, Romanova LG, Korneenko TV; et al. (1999). "Ouabain-sensitive H,K-ATPase: tissue-specific expression of the mammalian genes encoding the catalytic alpha subunit.". FEBS Lett. 440 (3): 320–4. doi:10.1016/S0014-5793(98)01483-5. PMID 9872395.
• Pestov NB, Korneenko TV, Adams G; et al. (2002). "Nongastric H-K-ATPase in rodent prostate: lobe-specific expression and apical localization.". Am. J. Physiol., Cell Physiol. 282 (4): C907–16. doi:10.1152/ajpcell.00258.2001. PMID 11880279.
• Reinhardt J, Kosch M, Lerner M; et al. (2002). "Stimulation of protein kinase C pathway mediates endocytosis of human nongastric H+-K+-ATPase, ATP1AL1.". Am. J. Physiol. Renal Physiol. 283 (2): F335–43. doi:10.1152/ajprenal.00226.2001. PMID 12110518.
• Takahashi Y, Sakai H, Kuragari M; et al. (2003). "Expression of ATP1AL1, a non-gastric proton pump, in human colorectum.". Jpn. J. Physiol. 52 (3): 317–21. doi:10.2170/jjphysiol.52.317. PMID 12230809.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li J, Codina J, Petroske E; et al. (2004). "The carboxy terminus of the colonic H(+), K(+)-ATPase alpha-subunit is required for stable beta subunit assembly and function.". Kidney Int. 65 (4): 1301–10. doi:10.1111/j.1523-1755.2004.00507.x. PMID 15086469.
• Johansson M, Jansson T, Pestov NB, Powell TL (2004). "Non-gastric H+/K+ ATPase is present in the microvillous membrane of the human placental syncytiotrophoblast.". Placenta 25 (6): 505–11. doi:10.1016/j.placenta.2003.11.008. PMID 15135233.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.