ATP5H

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
Identifiers
Symbols	ATP5H ; ATPQ
External IDs	MGI: 1918929 HomoloGene: 130552 IUPHAR: 804 GeneCards: ATP5H Gene
EC number	3.6.1.14
Gene ontology Molecular function • hydrogen ion transmembrane transporter activity • ATPase activity • transmembrane transporter activity Cellular component • mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) • nucleoplasm • cytoplasm • mitochondrion • mitochondrial inner membrane • mitochondrial proton-transporting ATP synthase complex • extracellular exosome Biological process • respiratory electron transport chain • mitochondrial ATP synthesis coupled proton transport • cellular metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10476	71679
Ensembl	ENSG00000167863	ENSMUSG00000034566
UniProt	O75947	Q9DCX2
RefSeq (mRNA)	NM_001003785	NM_027862
RefSeq (protein)	NP_001003785	NP_082138
Location (UCSC)	Chr 17: 75.04 – 75.05 Mb	Chr 11: 115.42 – 115.42 Mb
PubMed search

ATP synthase D chain, mitochondrial
Identifiers
Symbol	ATP5H
Pfam	PF05873
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The human gene ATP5H encodes subunit d of the enzyme mitochondrial ATP synthase.^[1][2]

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F₁, and the membrane-spanning component, F₀, which comprises the proton channel. The F₁ complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The F₀ seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the d subunit of the F₀ complex.

Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. In addition, three pseudogenes are located on chromosomes 9, 12 and 15.^[2]

References

1. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
2. "Entrez Gene: ATP5H ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d".

Further reading

• Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine.". Essays Biochem. 35: 3–18. PMID 12471886.
• Oster G, Wang H (2003). "Rotary protein motors.". Trends Cell Biol. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID 12628343.
• Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review).". Mol. Membr. Biol. 20 (1): 27–33. doi:10.1080/0968768031000066532. PMID 12745923.
• Higuti T, Kuroiwa K, Miyazaki S; et al. (1994). "The complete amino acid sequence of subunit d of rat liver mitochondrial H(+)-ATP synthase.". J. Biochem. 114 (5): 714–7. PMID 7509337.
• Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase.". Nature 391 (6666): 510–3. doi:10.1038/35185. PMID 9461222.
• Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase.". Nature 396 (6708): 279–82. doi:10.1038/24409. PMID 9834036.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Cross RL (2004). "Molecular motors: turning the ATP motor.". Nature 427 (6973): 407–8. doi:10.1038/427407b. PMID 14749816.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.