ATP5O

ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
Identifiers
Symbols	ATP5O ; ATPO; HMC08D05; OSCP
External IDs	OMIM: 600828 MGI: 106341 HomoloGene: 1283 GeneCards: ATP5O Gene
EC number	3.6.3.14
Gene ontology Molecular function • transporter activity • protein binding • drug binding • ATPase activity • transmembrane transporter activity • proton-transporting ATP synthase activity, rotational mechanism Cellular component • nucleus • mitochondrion • mitochondrial inner membrane • mitochondrial proton-transporting ATP synthase complex • plasma membrane • extracellular exosome Biological process • ATP biosynthetic process • proton transport • respiratory electron transport chain • mitochondrial ATP synthesis coupled proton transport • cellular metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	539	28080
Ensembl	ENSG00000241837	ENSMUSG00000022956
UniProt	P48047	Q9DB20
RefSeq (mRNA)	NM_001697	NM_138597
RefSeq (protein)	NP_001688	NP_613063
Location (UCSC)	Chr 21: 33.9 – 33.92 Mb	Chr 16: 91.68 – 91.93 Mb
PubMed search

ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5O gene.^[1]

The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance.^[1]

References

1. "Entrez Gene: ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (oligomycin sensitivity conferring protein)".

Further reading

• Chen H, Morris MA, Rossier C; et al. (1996). "Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.". Genomics 28 (3): 470–6. doi:10.1006/geno.1995.1176. PMID 7490082.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hattori M, Fujiyama A, Taylor TD; et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
• Aggeler R, Coons J, Taylor SW; et al. (2002). "A functionally active human F1F0 ATPase can be purified by immunocapture from heart tissue and fibroblast cell lines. Subunit structure and activity studies". J. Biol. Chem. 277 (37): 33906–12. doi:10.1074/jbc.M204538200. PMID 12110673.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Johnson KM, Chen X, Boitano A; et al. (2005). "Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423". Chem. Biol. 12 (4): 485–96. doi:10.1016/j.chembiol.2005.02.012. PMID 15850986.