ATP6AP2

ATPase, H+ transporting, lysosomal accessory protein 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3LBS​, 3LC8​
Identifiers
Symbols	ATP6AP2 ; APT6M8-9; ATP6IP2; ATP6M8-9; ELDF10; HT028; M8-9; MRXE; MRXSH; MSTP009; PRR; RENR; XMRE; XPDS
External IDs	OMIM: 300556 MGI: 1917745 HomoloGene: 38097 GeneCards: ATP6AP2 Gene
Gene ontology Molecular function • aspartic-type endopeptidase activity • receptor activity • protein binding • enzyme binding Cellular component • plasma membrane • external side of plasma membrane • integral component of membrane • neuron projection • cell body • extracellular exosome Biological process • angiotensin maturation • rostrocaudal neural tube patterning • positive regulation of Wnt signaling pathway • positive regulation of transforming growth factor beta1 production • regulation of MAPK cascade • cellular protein metabolic process • eye pigmentation • head morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10159	70495
Ensembl	ENSG00000182220	ENSMUSG00000031007
UniProt	O75787	Q9CYN9
RefSeq (mRNA)	NM_005765	NM_027439
RefSeq (protein)	NP_005756	NP_081715
Location (UCSC)	Chr X: 40.58 – 40.61 Mb	Chr X: 12.59 – 12.62 Mb
PubMed search

The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.^[1][2][3]

Function

The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.^[4]

This protein is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.^[3]

References

1. Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572.
2. Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis 7: 234–9. PMID 11590366.
3. "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".
4. Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. doi:10.1172/JCI14276. PMC 150992. PMID 12045255.

Further reading

• Kaneshiro Y, Ichihara A, Sakoda M; et al. (2007). "Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats.". J. Am. Soc. Nephrol. 18 (6): 1789–95. doi:10.1681/ASN.2006091062. PMID 17494887.
• Schefe JH, Menk M, Reinemund J; et al. (2007). "A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein.". Circ. Res. 99 (12): 1355–66. doi:10.1161/01.RES.0000251700.00994.0d. PMID 17082479.
• Kaneshiro Y, Ichihara A, Takemitsu T; et al. (2006). "Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats.". Kidney Int. 70 (4): 641–6. doi:10.1038/sj.ki.5001627. PMID 16807542.
• Burcklé CA, Jan Danser AH, Müller DN; et al. (2006). "Elevated blood pressure and heart rate in human renin receptor transgenic rats.". Hypertension 47 (3): 552–6. doi:10.1161/01.HYP.0000199912.47657.04. PMID 16401765.
• Huang Y, Wongamorntham S, Kasting J; et al. (2006). "Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.". Kidney Int. 69 (1): 105–13. doi:10.1038/sj.ki.5000011. PMID 16374430.
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Ramser J, Abidi FE, Burckle CA; et al. (2005). "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor.". Hum. Mol. Genet. 14 (8): 1019–27. doi:10.1093/hmg/ddi094. PMID 15746149.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hedera P, Alvarado D, Beydoun A, Fink JK (2002). "Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4.". Ann. Neurol. 51 (1): 45–50. doi:10.1002/ana.10051. PMID 11782983.
• Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.

External links

• ATP6AP2 human gene location in the UCSC Genome Browser.
• ATP6AP2 human gene details in the UCSC Genome Browser.