ATP6V0D2

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
Identifiers
Symbols	ATP6V0D2 ; ATP6D2; VMA6
External IDs	HomoloGene: 72090 GeneCards: ATP6V0D2 Gene
EC number	3.6.3.14
Gene ontology Molecular function • protein binding • hydrogen ion transmembrane transporter activity Cellular component • early endosome • endosome membrane • membrane • apical plasma membrane • vacuolar proton-transporting V-type ATPase complex • phagocytic vesicle membrane • proton-transporting V-type ATPase, V0 domain • extracellular exosome Biological process • cellular iron ion homeostasis • insulin receptor signaling pathway • ATP hydrolysis coupled proton transport • transferrin transport • ion transmembrane transport • interaction with host • transmembrane transport • phagosome maturation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	245972	242341
Ensembl	ENSG00000147614	ENSMUSG00000028238
UniProt	Q8N8Y2	Q80SY3
RefSeq (mRNA)	NM_152565	NM_175406
RefSeq (protein)	NP_689778	NP_780615
Location (UCSC)	Chr 8: 85.99 – 86.15 Mb	Chr 4: 19.88 – 19.92 Mb
PubMed search

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 is a protein in humans that is encoded by the ATP6V0D2 gene. ^[1] It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption. ^[2]

References

1. "Entrez Gene: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2". Retrieved 2012-11-12.
2. H, Wu; G, Xu; YP, Li (May 2009). "Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption". Journal of Bone and Mineral Research 24 (5): 871 - 885. doi:10.1359/jbmr.081239. PMID 19113919. Retrieved 29 January 2015.

Further reading