ATP6V1E2

ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
Identifiers
Symbols	ATP6V1E2 ; ATP6E1; ATP6EL2; ATP6V1EL2; VMA4
External IDs	MGI: 1922165 HomoloGene: 41770 GeneCards: ATP6V1E2 Gene
Gene ontology Molecular function • protein binding • hydrogen-exporting ATPase activity, phosphorylative mechanism • proton-transporting ATPase activity, rotational mechanism Cellular component • acrosomal vesicle • cytosol • proton-transporting two-sector ATPase complex, catalytic domain Biological process • cellular iron ion homeostasis • insulin receptor signaling pathway • ATP hydrolysis coupled proton transport • transferrin transport • ion transmembrane transport • interaction with host • transmembrane transport • phagosome maturation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90423	74915
Ensembl	ENSG00000250565	ENSMUSG00000053375
UniProt	Q96A05	Q9D593
RefSeq (mRNA)	NM_080653	NM_029121
RefSeq (protein)	NP_542384	NP_083397
Location (UCSC)	Chr 2: 46.49 – 46.54 Mb	Chr 17: 86.94 – 86.95 Mb
PubMed search

V-type proton ATPase subunit E 2 is an enzyme that in humans is encoded by the ATP6V1E2 gene.^[1][2]

References

1. Imai-Senga Y, Sun-Wada GH, Wada Y, Futai M (May 2002). "A human gene, ATP6E1, encoding a testis-specific isoform of H(+)-ATPase subunit E". Gene 289 (1–2): 7–12. doi:10.1016/S0378-1119(02)00542-5. PMID 12036578.
2. "Entrez Gene: ATP6V1E2 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2".

Further reading

• Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nat. Rev. Mol. Cell Biol. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511.
• Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Lett. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495.
• Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biol. Cell 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263.
• Breton S, Wiederhold T, Marshansky V; et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells". J. Biol. Chem. 275 (24): 18219–24. doi:10.1074/jbc.M909857199. PMID 10748165.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Smith AN, Lovering RC, Futai M; et al. (2003). "Revised nomenclature for mammalian vacuolar-type H+ -ATPase subunit genes". Mol. Cell 12 (4): 801–3. doi:10.1016/S1097-2765(03)00397-6. PMID 14580332.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.