AUP1

Ancient ubiquitous protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EKF​
Identifiers
Symbol	AUP1
External IDs	OMIM: 602434 MGI: 107789 HomoloGene: 7239 GeneCards: AUP1 Gene
Gene ontology Molecular function • protein binding Cellular component • endoplasmic reticulum membrane • membrane • integral component of membrane • extracellular exosome Biological process • retrograde protein transport, ER to cytosol Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	550	11993
Ensembl	ENSG00000115307	ENSMUSG00000068328
UniProt	Q9Y679	P70295
RefSeq (mRNA)	NM_181575	NM_001025446
RefSeq (protein)	NP_853553	NP_001288578
Location (UCSC)	Chr 2: 74.53 – 74.53 Mb	Chr 6: 83.05 – 83.06 Mb
PubMed search

Ancient ubiquitous protein 1 is a protein that in humans is encoded by the AUP1 gene.^[1][2][3]

Function

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.^[3]

Interactions

AUP1 has been shown to interact with ITGA2B.^[2]

References

1. Jang W, Weber JS, Bashir R, Bushby K, Meisler MH (Jan 1997). "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13". Genomics 36 (2): 366–8. doi:10.1006/geno.1996.0477. PMID 8812468.
2. Kato A, Kawamata N, Tamayose K, Egashira M, Miura R, Fujimura T, Murayama K, Oshimi K (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J Biol Chem 277 (32): 28934–41. doi:10.1074/jbc.M204340200. PMID 12042322.
3. "Entrez Gene: AUP1 ancient ubiquitous protein 1".

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Karpisheva KV, Tauber B, Kisliakova TV, Dobner T (2003). "[A new human cellular protein AUP1. III. The intracellular localization of AUP1 protein in different human and rat cell lines]". Tsitologiia 44 (9): 846–51. PMID 12534238.
• Karpisheva KV, Touber B, Kisliakova TV, Dobner T (2003). "[A new human cellular protein AUP1. II. cDNA cloning, genomic organization of Aup1 gene ans [sic] preliminary characterization of human AUP1 protein]". Tsitologiia 44 (9): 839–45. PMID 12534237.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.