AZI2
| 5-azacytidine induced 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | AZI2 ; AZ2; NAP1; TILP | ||||||||||||
| External IDs | OMIM: 609916 MGI: 1351332 HomoloGene: 8443 GeneCards: AZI2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 64343 | 27215 | |||||||||||
| Ensembl | ENSG00000163512 | ENSMUSG00000039285 | |||||||||||
| UniProt | Q9H6S1 | Q9QYP6 | |||||||||||
| RefSeq (mRNA) | NM_001134432 | NM_001048146 | |||||||||||
| RefSeq (protein) | NP_001127904 | NP_001041611 | |||||||||||
| Location (UCSC) |
Chr 3: 28.32 – 28.35 Mb |
Chr 9: 118.04 – 118.07 Mb | |||||||||||
| PubMed search | |||||||||||||
5-azacytidine-induced protein 2 is a protein that in humans is encoded by the AZI2 gene.[1][2]
AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003).[supplied by OMIM][2]
References
- ↑ Miyagawa J, Muguruma M, Aoto H, Suetake I, Nakamura M, Tajima S (Jan 2000). "Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus". Gene 240 (2): 289–95. doi:10.1016/S0378-1119(99)00450-3. PMID 10580148.
- 1 2 "Entrez Gene: AZI2 5-azacytidine induced 2".
Further reading
- Funami K, Sasai M, Ohba Y, et al. (2007). "Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA". J. Immunol. 179 (10): 6867–72. doi:10.4049/jimmunol.179.10.6867. PMID 17982077.
- Sasai M, Shingai M, Funami K, et al. (2007). "NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction". J. Immunol. 177 (12): 8676–83. doi:10.4049/jimmunol.177.12.8676. PMID 17142768.
- Sasai M, Oshiumi H, Matsumoto M, et al. (2005). "Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation". J. Immunol. 174 (1): 27–30. doi:10.4049/jimmunol.174.1.27. PMID 15611223.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Fujita F, Taniguchi Y, Kato T, et al. (2003). "Identification of NAP1, a Regulatory Subunit of IκB Kinase-Related Kinases That Potentiates NF-κB Signaling". Mol. Cell. Biol. 23 (21): 7780–93. doi:10.1128/MCB.23.21.7780-7793.2003. PMC 207563. PMID 14560022.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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