AZIN1

Antizyme inhibitor 1
Identifiers
Symbols	AZIN1 ; AZI; AZIA1; OAZI; OAZIN; ODC1L
External IDs	OMIM: 607909 MGI: 1859169 HomoloGene: 22933 GeneCards: AZIN1 Gene
Gene ontology Molecular function • ornithine decarboxylase activity • protein binding • ornithine decarboxylase activator activity Cellular component • nucleus • cytoplasm • cytosol Biological process • regulation of cellular amino acid metabolic process • putrescine biosynthetic process from ornithine • cellular nitrogen compound metabolic process • negative regulation of protein catabolic process • positive regulation of catalytic activity • small molecule metabolic process • positive regulation of polyamine transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51582	54375
Ensembl	ENSG00000155096	ENSMUSG00000037458
UniProt	O14977	O35484
RefSeq (mRNA)	NM_001301668	NM_001102458
RefSeq (protein)	NP_001288597	NP_001095928
Location (UCSC)	Chr 8: 102.83 – 102.89 Mb	Chr 15: 38.49 – 38.52 Mb
PubMed search

Antizyme inhibitor 1 is a protein that in humans is encoded by the AZIN1 gene.^[1][2][3]

Ornithine decarboxylase (ODC) catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. Ornithine decarboxylase antizymes play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein encoded by this gene is highly similar to ODC. It binds to ODC antizyme and stabilizes ODC, thus inhibiting antizyme-mediated ODC degradation. Two alternatively spliced transcript variants have been found for this gene.^[3]

References

1. Koguchi K, Kobayashi S, Hayashi T, Matsufuji S, Murakami Y, Hayashi S (Nov 1997). "Cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme inhibitor". Biochim Biophys Acta 1353 (3): 209–16. doi:10.1016/s0167-4781(97)00106-1. PMID 9349715.
2. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
3. "Entrez Gene: AZIN1 antizyme inhibitor 1".

Further reading

• Murakami Y, Matsufuji S, Hayashi S; et al. (2000). "Degradation of ornithine decarboxylase by the 26S proteasome". Biochem. Biophys. Res. Commun. 267 (1): 1–6. doi:10.1006/bbrc.1999.1706. PMID 10623564.
• Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imabayashi H, Mori T, Gojo S; et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Reuter TY, Medhurst AL, Waisfisz Q; et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.