AZIN2

Antizyme inhibitor 2
Identifiers
Symbols	AZIN2 ; ADC; AZI2; AZIB1; ODC-p; ODC1L; ODCp
External IDs	OMIM: 608353 MGI: 2442093 HomoloGene: 62172 GeneCards: AZIN2 Gene
EC number	4.1.1.19
Gene ontology Molecular function • ornithine decarboxylase activity • protein binding • putrescine transmembrane transporter activity • ornithine decarboxylase activator activity Cellular component • nucleus • cytoplasm • mitochondrion • cis-Golgi network • trans-Golgi network • cytosol • transport vesicle • axon • dendrite • cytoplasmic vesicle • endoplasmic reticulum-Golgi intermediate compartment membrane • perikaryon • perinuclear region of cytoplasm • granular vesicle Biological process • polyamine metabolic process • spermatogenesis • putrescine transport • putrescine biosynthetic process from ornithine • cellular nitrogen compound metabolic process • negative regulation of protein catabolic process • positive regulation of catalytic activity • small molecule metabolic process • agmatine biosynthetic process • trans-Golgi network membrane organization • positive regulation of polyamine transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	113451	242669
Ensembl	ENSG00000142920	ENSMUSG00000028789
UniProt	Q96A70	Q8BVM4
RefSeq (mRNA)	NM_001293562	NM_001301841
RefSeq (protein)	NP_001280491	NP_001288770
Location (UCSC)	Chr 1: 33.08 – 33.12 Mb	Chr 4: 128.93 – 128.96 Mb
PubMed search

Antizyme inhibitor 2 (AzI2) also known as arginine decarboxylase (ADC) is an enzyme that in humans is encoded by the AZIN2 gene.^[1][2][3]

References

1. Pitkänen LT, Heiskala M, Andersson LC (2001). "Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes". Biochem. Biophys. Res. Commun. 287 (5): 1051–7. doi:10.1006/bbrc.2001.5703. PMID 11587527.
2. Zhu MY, Iyo A, Piletz JE, Regunathan S (2004). "Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine". Biochim. Biophys. Acta 1670 (2): 156–64. doi:10.1016/j.bbagen.2003.11.006. PMID 14738999.
3. "Entrez Gene: ADC arginine decarboxylase".

Further reading

• Nagase T, Kikuno R, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Res. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
• Coleman CS, Hu G, Pegg AE (2004). "Putrescine biosynthesis in mammalian tissues". Biochem. J. 379 (Pt 3): 849–55. doi:10.1042/BJ20040035. PMC 1224126. PMID 14763899.
• Choi KS, Suh YH, Kim WH, Lee TH, Jung MH (2005). "Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity". Biochem. Biophys. Res. Commun. 328 (1): 206–12. doi:10.1016/j.bbrc.2004.11.172. PMID 15670771.
• López-Contreras AJ, López-Garcia C, Jiménez-Cervantes C, Cremades A, Peñafiel R (2006). "Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity". J. Biol. Chem. 281 (41): 30896–906. doi:10.1074/jbc.M602840200. PMID 16916800.
• Tian H, Liu X, Zhang B, Sun Q, Sun D (2007). "Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth". Acta Biochim. Biophys. Sin. (Shanghai) 39 (6): 423–30. doi:10.1111/j.1745-7270.2007.00294.x. PMID 17558447.
• Levin VA, Jochec JL, Shantz LM, Aldape KD (2007). "Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy". Int. J. Cancer 121 (10): 2279–83. doi:10.1002/ijc.22914. PMID 17582600.
• Kanerva K, Mäkitie LT, Pelander A, Heiskala M, Andersson LC (2008). "Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase". Biochem. J. 409 (1): 187–92. doi:10.1042/BJ20071004. PMID 17900240.