Acetylcysteinamide

Acetylcysteinamide
Systematic (IUPAC) name


(2S)-2-Acetamido-3-sulfanylpropanamide
Identifiers
CAS Number	10061-64-0 15394-73-7 (racemic)
PubChem	CID 9942232
ChemSpider	74304
Chemical data
Formula	C₅H₁₀N₂O₂S
Molar mass	162.21 g/mol
SMILES SC[C@H](C(=O)N)NC(=O)C
InChI InChI=1S/C5H10N2O2S/c1-3(8)7-4(2-10)5(6)9/h4,10H,2H2,1H3,(H2,6,9)(H,7,8)/t4-/m1/s1 Key:UJCHIZDEQZMODR-SCSAIBSYSA-N
Physical data
Density	1.227 g/cm³
Boiling point	308 °C (586 °F)
Solubility in water	33300 mg/mL (20 °C)

N-Acetylcysteine amide (abbrev. NACA, AD4 and also known as acetylcysteinamide) is a amide derivative of N-acetylcysteine that appears to have better blood–brain barrier permeability and bioavailability and a similar antioxidant capability.^[1]

References

↑ Sunitha, K.; Hemshekhar, M.; Thushara, R. M.; Santhosh, M. Sebastin; Yariswamy, M.; Kemparaju, K.; Girish, K. S. (2013). "N-Acetylcysteine amide: A derivative to fulfill the promises of N-Acetylcysteine". Free Radical Research 47 (5): 357–67. doi:10.3109/10715762.2013.781595. PMID 23472882.

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