Acidophile (histology)

An acidophile (or acidophil, or, as an adjectival form, acidophilic) describes is a term used by histologists to describe a particular staining pattern of cells and tissues when using haematoxylin and eosin stains. Specifically, the name refers to structures which "love" acid, and take it up readily.

It describes the microscopic appearance of cells and tissues, as seen down the microscope, after a histological section has been stained with an acidic dye. The most common such dye is eosin, which stains acidophilic substances red and is the source of the related term eosinophilic. Note that a single cell can have both acidophilic substances/organelles and basophilic substances/organelles, albeit some have historically had so much of one stain that the cell itself is called a eosinophil.

Microbial and histological stains

Iron/hemosiderin	Prussian blue

Lipids	Sudan stain Sudan II Sudan III Sudan IV Oil Red O Sudan Black B

Carbohydrates	Periodic acid-Schiff stain

Amyloid	Congo red

Bacteria	Gram staining Methyl violet/Gentian violet Safranin Ziehl–Neelsen stain/acid-fast Carbol fuchsin/Fuchsine Methylene blue Auramine-rhodamine stain Auramine O Rhodamine B

Connective tissue	trichrome stain: Masson's trichrome stain/Lillie's trichrome Light Green SF yellowish Biebrich scarlet Phosphomolybdic acid Fast Green FCF Van Gieson's stain

Other	H&E stain Haematoxylin Eosin Y Silver stain Grocott's methenamine silver stain Warthin–Starry stain Methyl blue Wright's stain Giemsa stain Gömöri trichrome stain Neutral red Janus Green B Alcian blue stain Movat's stain

Tissue stainability	Acidophilic Basophilic Chromophobic

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Acidophile (histology)

See also