Acrocylindropepsin

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Acrocylindropepsin (EC 3.4.23.28, Acrocylindrium proteinase, Acrocylindrium acid proteinase) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Preference for hydrophobic residues at P1 and P1'. Action on the B chain of insulin is generally similar to that of pepsin A, but it also cleaves Leu6-Cys(SO₃H), Glu²¹-Arg and Asn³-Gln, although not Gln⁴-His

This enzyme is present in fungus Acrocylindrium sp.

References

↑ Uchino, F., Kurono, Y. and Doi, S. (1967). "Purification and some properties of crystalline acid protease from Acrocylindrium sp". Agric. Biol. Chem. 31: 428–434. doi:10.1271/bbb1961.31.428.
↑ Ichihara, S. and Uchino, F. (1975). "The specificity of acid proteinase from Acrocylindrium". Agric. Biol. Chem. 39: 423–428. doi:10.1271/bbb1961.39.423.
↑ Takahashi, K. and Chang, W.-J. (1976). "The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy)propane and pepstatin". J. Biochem. (Tokyo) 80: 497–506. PMID 10290.

External links

Acrocylindropepsin at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: aspartate proteases (EC 3.4.23)

Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2

Pathogenic	Plasmepsin HIV-1 protease

Plant	Nepenthesin

Cathepsin	D E

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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