Adam Bogdanove

Adam Bogdanove
Born 1964
Nationality American
Fields Plant Pathology, Bioengineering
Institutions Cornell University, Boyce Thompson Institute
Alma mater Yale University, Cornell University
Known for TAL effectors, Genome editing
Website

Adam J. Bogdanove (born 1964) is a Professor of Plant Pathology at Cornell University.[1] He is most notable for his central role in the development of TAL effector based DNA targeting reagents, following his discovery of TAL effector modularity with Matthew Moscou in 2009.[2] Since, he has been a leader in the field, pioneering applications in genome editing and contributing one of the most widely used methods for designing custom TAL effectors using Golden Gate Cloning.[3] Bogdanove is now widely recognized for revolutionizing the area of DNA targeting, along with scientists such as Jennifer Doudna and Emmanuelle Charpentier.

Education

Bogdanove earned his Bachelor of Science degree in Biology from Yale University in 1987, and his Ph.D. in Plant Pathology from Cornell University in 1997,[4] going on to do postdoctoral work at Purdue University.

Research and career

Bogdanove's present research focuses on the pathogen Xanthomonas oryzae and its interactions with species of rice. A significant portion of his work uncovered the mechanisms by which TAL effectors increase disease susceptibility by manipulating host gene expression. Further work has paved the way for genome editing technologies like CRISPR and their applications, which use modified proteins to induce targeted changes in plant and animal DNA sequences.

References

  1. ↑ "People in PPPMB: Adam Bogdanove". Cornell University CALS. Cornell University. Retrieved 12 April 2016.
  2. ↑ Moscou MJ, Bogdanove AJ (December 2009). "A simple cipher governs DNA recognition by TAL effectors". Science 326 (5959): 1501. Bibcode:2009Sci...326.1501M. doi:10.1126/science.1178817. PMID 19933106.
  3. ↑ Cermak, T.; Doyle, E. L.; Christian, M.; Wang, L.; Zhang, Y.; Schmidt, C.; Baller, J. A.; Somia, N. V.; Bogdanove, A. J.; Voytas, D. F. (2011). "Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting". Nucleic Acids Research 39 (12): e82. doi:10.1093/nar/gkr218. PMC: 3130291. PMID 21493687.
  4. ↑ "People in PPPMB: Adam Bogdanove". Cornell University CALS. Cornell University. Retrieved 12 April 2016.
This article is issued from Wikipedia - version of the Friday, April 22, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.