Adenylyl-sulfate reductase

adenylyl-sulfate reductase
Identifiers
EC number 1.8.99.2
CAS number 9027-75-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Adenylyl-sulfate reductase (EC 1.8.99.2) is an enzyme that catalyzes the chemical reaction

AMP + sulfite + acceptor \rightleftharpoons adenylyl sulfate + reduced acceptor

The 3 substrates of this enzyme are AMP, sulfite, and an acceptor, whereas its two products are adenylyl sulfate and a reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with other acceptors. The systematic name of this enzyme class is AMP,sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming). Other names in common use include adenosine phosphosulfate reductase, adenosine 5'-phosphosulfate reductase, APS-reductase, APS reductase, AMP, sulfite:(acceptor) oxidoreductase, and (adenosine-5'-phosphosulfate-forming). This enzyme participates in selenoamino acid metabolism and sulfur metabolism. It has 2 cofactors: FAD, and Iron.

Structural studies

As of late 2014, 6 structures have been solved for this class of enzymes, with PDB accession codes 1JNR, 1JNZ, 2FJA, 2FJB, 2FJD, and 2FJE.

References

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