Adipose differentiation-related protein
| Perilipin 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | PLIN2 ; ADFP; ADRP | ||||||||||
| External IDs | OMIM: 103195 MGI: 87920 HomoloGene: 872 GeneCards: PLIN2 Gene | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 123 | 11520 | |||||||||
| Ensembl | ENSG00000147872 | ENSMUSG00000028494 | |||||||||
| UniProt | Q99541 | P43883 | |||||||||
| RefSeq (mRNA) | NM_001122 | NM_007408 | |||||||||
| RefSeq (protein) | NP_001113 | NP_031434 | |||||||||
| Location (UCSC) |
Chr 9: 19.11 – 19.15 Mb |
Chr 4: 86.65 – 86.67 Mb | |||||||||
| PubMed search | |||||||||||
Adipose differentiation-related protein, also known as perilipin 2 (PLIN2), ADRP or adipophilin, is a protein which in humans is encoded by the ADFP gene.[1]
Function
Adipocyte differentiation-related protein is associated with the globule surface membrane material. This protein is a major constituent of the globule surface. Increase in mRNA levels is one of the earliest indications of adipocyte differentiation.[1]
Pre-adipocytes are undifferentiated fibroblasts that can be stimulated to form adipocytes. Recent studies shed light into potential molecular mechanisms in the fate determination of pre-asipocytes although the exact lineage of adipocyte is still unclear.[2][3]
References
- 1 2 "Entrez Gene: ADFP adipose differentiation-related protein".
- ↑ "Scientists closer to finding what causes the birth of a fat cell". ScienceDaily.
- ↑ Coskun, Huseyin; Summerfield, Taryn LS; Kniss, Douglas A; Friedman, Avner (2010). "Mathematical modeling of preadipocyte fate determination". Journal of Theoretical Biology 265 (1): 87–94. doi:10.1016/j.jtbi.2010.03.047. PMID 20385145..
Further reading
- Bosma M, Hesselink MKC, Sparks LM; et al. (2012). "Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels.". Diabetes. 61 (11): 2679–2690. doi:10.2337/db11-1402. PMID 22807032.
- Jiang HP, Serrero G (1992). "Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein.". Proc. Natl. Acad. Sci. U.S.A. 89 (17): 7856–60. doi:10.1073/pnas.89.17.7856. PMC 49813. PMID 1518805.
- Heid HW, Schnölzer M, Keenan TW (1997). "Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane.". Biochem. J. 320 (3): 1025–30. PMC 1218030. PMID 9003395.
- Heid HW, Moll R, Schwetlick I; et al. (1998). "Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases.". Cell Tissue Res. 294 (2): 309–21. doi:10.1007/s004410051181. PMID 9799447.
- Schultz CJ, Torres E, Londos C, Torday JS (2002). "Role of adipocyte differentiation-related protein in surfactant phospholipid synthesis by type II cells.". Am. J. Physiol. Lung Cell Mol. Physiol. 283 (2): L288–96. doi:10.1152/ajplung.00204.2001. PMID 12114189.
- Saarikoski ST, Rivera SP, Hankinson O (2002). "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia.". FEBS Lett. 530 (1-3): 186–90. doi:10.1016/S0014-5793(02)03475-0. PMID 12387890.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Targett-Adams P, Chambers D, Gledhill S; et al. (2003). "Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein.". J. Biol. Chem. 278 (18): 15998–6007. doi:10.1074/jbc.M211289200. PMID 12591929.
- Bildirici I, Roh CR, Schaiff WT; et al. (2004). "The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor.". J. Clin. Endocrinol. Metab. 88 (12): 6056–62. doi:10.1210/jc.2003-030628. PMID 14671211.
- Larigauderie G, Furman C, Jaye M; et al. (2005). "Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis.". Arterioscler. Thromb. Vasc. Biol. 24 (3): 504–10. doi:10.1161/01.ATV.0000115638.27381.97. PMID 14707038.
- Nakamura N, Akashi T, Taneda T; et al. (2004). "ADRP is dissociated from lipid droplets by ARF1-dependent mechanism.". Biochem. Biophys. Res. Commun. 322 (3): 957–65. doi:10.1016/j.bbrc.2004.08.010. PMID 15336557.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Robenek H, Lorkowski S, Schnoor M, Troyer D (2005). "Spatial integration of TIP47 and adipophilin in macrophage lipid bodies.". J. Biol. Chem. 280 (7): 5789–94. doi:10.1074/jbc.M407194200. PMID 15545278.
- Masuda Y, Itabe H, Odaki M; et al. (2006). "ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells.". J. Lipid Res. 47 (1): 87–98. doi:10.1194/jlr.M500170-JLR200. PMID 16230742.
- Tobin KA, Harsem NK, Dalen KT; et al. (2006). "Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line.". J. Lipid Res. 47 (4): 815–23. doi:10.1194/jlr.M500527-JLR200. PMID 16391323.
- Dalen KT, Ulven SM, Arntsen BM; et al. (2006). "PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.". J. Lipid Res. 47 (5): 931–43. doi:10.1194/jlr.M500459-JLR200. PMID 16489205.
- Ohsaki Y, Maeda T, Maeda M; et al. (2006). "Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft.". Biochem. Biophys. Res. Commun. 347 (1): 279–87. doi:10.1016/j.bbrc.2006.06.074. PMID 16808905.
- Larigauderie G, Cuaz-Pérolin C, Younes AB; et al. (2006). "Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation.". FEBS J. 273 (15): 3498–510. doi:10.1111/j.1742-4658.2006.05357.x. PMID 16884492.
- Magra AL, Mertz PS, Torday JS, Londos C (2007). "Role of adipose differentiation-related protein in lung surfactant production: a reassessment.". J. Lipid Res. 47 (11): 2367–73. doi:10.1194/jlr.M600157-JLR200. PMID 16936283.
- Yao M, Huang Y, Shioi K; et al. (2007). "Expression of adipose differentiation-related protein: a predictor of cancer-specific survival in clear cell renal carcinoma.". Clin. Cancer Res. 13 (1): 152–60. doi:10.1158/1078-0432.CCR-06-1877. PMID 17200350.
- Sarov-Blat L, Kiss RS, Haidar B; et al. (2007). "Predominance of a proinflammatory phenotype in monocyte-derived macrophages from subjects with low plasma HDL-cholesterol.". Arterioscler. Thromb. Vasc. Biol. 27 (5): 1115–22. doi:10.1161/ATVBAHA.106.138990. PMID 17322100.
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