Aldehyde oxidase 1

Aldehyde oxidase 1
Identifiers
Symbols	AOX1 ; AO; AOH1
External IDs	OMIM: 602841 MGI: 88035 HomoloGene: 68165 ChEMBL: 3257 GeneCards: AOX1 Gene
EC number	1.2.3.1
Gene ontology Molecular function • aldehyde oxidase activity • xanthine dehydrogenase activity • iron ion binding • UDP-N-acetylmuramate dehydrogenase activity • electron carrier activity • molybdopterin cofactor binding • flavin adenine dinucleotide binding • NAD binding • 2 iron, 2 sulfur cluster binding Cellular component • cytoplasm • cytosol • extracellular exosome Biological process • vitamin metabolic process • water-soluble vitamin metabolic process • inflammatory response • vitamin B6 metabolic process • small molecule metabolic process • oxidation-reduction process • reactive oxygen species metabolic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	316	11761
Ensembl	ENSG00000138356	ENSMUSG00000063558
UniProt	Q06278	O54754
RefSeq (mRNA)	NM_001159	NM_009676
RefSeq (protein)	NP_001150	NP_033806
Location (UCSC)	Chr 2: 200.59 – 200.68 Mb	Chr 1: 58.03 – 58.11 Mb
PubMed search

Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.^[1][2]

Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.^[1]

Clinical significance

Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.^[2]

See also

• MOCOS

References

1. "Entrez Gene: aldehyde oxidase 1".
2. Berger R, Mezey E, Clancy KP, Harta G, Wright RM, Repine JE, Brown RH, Brownstein M, Patterson D (March 1995). "Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis". Somat. Cell Mol. Genet. 21 (2): 121–31. doi:10.1007/BF02255787. PMID 7570184.

Further reading

• Wang AG, Yoon SY, Oh JH; et al. (2006). "Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags.". Biochem. Biophys. Res. Commun. 345 (3): 1022–32. doi:10.1016/j.bbrc.2006.04.175. PMID 16712791.
• Smith MA, Marinaki AM, Arenas M; et al. (2009). "Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease.". Aliment. Pharmacol. Ther. 30 (4): 375–84. doi:10.1111/j.1365-2036.2009.04057.x. PMID 19500084.
• Rose JE, Behm FM, Drgon T; et al. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7-8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Sigruener A, Buechler C, Orsó E; et al. (2007). "Human aldehyde oxidase 1 interacts with ATP-binding cassette transporter-1 and modulates its activity in hepatocytes.". Horm. Metab. Res. 39 (11): 781–9. doi:10.1055/s-2007-992129. PMID 17992631.
• Ichida K, Matsumura T, Sakuma R; et al. (2001). "Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II.". Biochem. Biophys. Res. Commun. 282 (5): 1194–200. doi:10.1006/bbrc.2001.4719. PMID 11302742.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Alfaro JF, Joswig-Jones CA, Ouyang W; et al. (2009). "Purification and mechanism of human aldehyde oxidase expressed in Escherichia coli.". Drug Metab. Dispos. 37 (12): 2393–8. doi:10.1124/dmd.109.029520. PMC 2784701. PMID 19741035.
• Rodrigues AD (1994). "Comparison of levels of aldehyde oxidase with cytochrome P450 activities in human liver in vitro.". Biochem. Pharmacol. 48 (1): 197–200. doi:10.1016/0006-2952(94)90240-2. PMID 8043023.
• Wright RM, Vaitaitis GM, Wilson CM; et al. (1993). "cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10690–4. doi:10.1073/pnas.90.22.10690. PMC 47843. PMID 8248161.
• Buechler C, Boettcher A, Bared SM; et al. (2002). "The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex.". Biochem. Biophys. Res. Commun. 293 (2): 759–65. doi:10.1016/S0006-291X(02)00303-0. PMID 12054535.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ross CJ, Katzov-Eckert H, Dubé MP; et al. (2009). "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.". Nat. Genet. 41 (12): 1345–9. doi:10.1038/ng.478. PMID 19898482.