Allan Basbaum

Allan Irwin Basbaum PhD, FRS is a Canadian born medical researcher, and professor and chair of the Department of Anatomy University of California, San Francisco.^[1][2] He is a Fellow of the American Academy of Arts and Sciences. He is a member of the Institute of Medicine.^[3] and a Fellow of the Royal Society in the United Kingdom. From 2003 to 2012 he was Editor-in-Chief of Pain, the journal of the International Association for the Study of Pain.

Works

• Allan I. Basbaum and David Julius, "Toward Better Pain Control", Scientific American, May 22, 2006

Selected Publications

• Malmberg, A.B.; Chen, C.; Tonegawa, S.; Basbaum, A.I. (1997). "Preserved acute pain and reduced neuropathic pain in mice lacking PKCg". Science 278: 279–283. doi:10.1126/science.278.5336.279. PMID 9323205.
• Liu, H.; Mantyh, P.W.; Basbaum, A.I. (1997). "NMDA-receptor regulation of substance P release from primary afferent nociceptors". Nature 386: 721–724. doi:10.1038/386721a0.
• Cao, Y.Q.; Mantyh, P.W.; Carlson, E.J.; Gillespie, A.-M.; Epstein, C.J.; Basbaum, A.I. (1998). "Primary afferent tachykinins are required to experience moderate to intense pain". Nature 392: 390–394. doi:10.1038/32897.
• Caterina, M.J.; Leffler, A.; Malmberg, A.B.; Martin, W.F.; Trafton, J.A.; Petersen-Zeitz, K; Koltzenburg, M.; Basbaum, A.I.; Julius, D. (2000). "Impaired nociception and pain sensation in mice lacking the capsaicin receptor". Science 288: 306–313. doi:10.1126/science.288.5464.306. PMID 10764638.
• Trafton, J.A.; Abbadie, C.; Marek, K.; Basbaum, A.I. (2000). "Postsynaptic signaling via the µ opioid receptor: Responses of dorsal horn neurons to exogenous opioids and noxious stimulation". J. Neurosci 20: 8578–8584.
• Neumann, S.; Bradke, F.; Tessier-Lavigne, M.; Basbaum, A.I. (2002). "Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation". Neuron 34: 885–893. doi:10.1016/s0896-6273(02)00702-x.
• Braz, J.M.; Nassar, M.A.; Wood, J.N.; Basbaum, A.I. (2005). "Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor". Neuron 47: 787–93. doi:10.1016/j.neuron.2005.08.015.
• Ahn, A.H.; Basbaum, A.I. (2006). "Tissue injury regulates serotonin 1D receptor expression: implications for the control of migraine and inflammatory pain". J Neurosci 26: 8332–8338. doi:10.1523/jneurosci.1989-06.2006.
• Bautista, D.M.; Jordt, S.E.; Nikai, T.; Tsuruda, P.R.; Read, A.J.; Poblete, J.; Yamoah, E.H.; Basbaum, A.I.; Julius, D. (2006). "TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents". Cell 124: 1269–1282. doi:10.1016/j.cell.2006.02.023.
• Neumann, S.; Braz, J.M.; Skinner, K.; Llewellyn-Smith, I.J.; Basbaum, A.I. (2008). "Innocuous,not noxious,input activates "PKC" interneurons of the spinal dorsal horn via myelinated afferent fibers". J Neurosci 28: 7936–7944. doi:10.1523/jneurosci.1259-08.2008.
• Imamachi, N.; Park, G.H.; Lee, H.; Anderson, D.J.; Simon, M.I.; Basbaum, A.I.; Han, S.K. (2009). "TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms". Proc Natl Acad Sci USA 106: 11330–11305. doi:10.1073/pnas.0905605106.
• Cavanaugh, D.J.; Lee, H.; Lo, L.; Shlelds, S.D.; Zylka, M.J.; Basbaum, A.I.; Anderson, D.J. (2009). "Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli". Proc Natl Acad Sci USA 106: 9075–9080. doi:10.1073/pnas.0901507106.
• Scherrer, G.; Imamachi, N.; Cao, Y-Q; Contet, C.; Mennicken, F.; O'Donnell, D.; Kieffer, B.L.; Basbaum, A.I. (2009). "Dissociation of the opioid receptor mechanisms that control mechanical and heat pain". Cell 137: 1148–1169. doi:10.1016/j.cell.2009.04.019.
• Seal, R.P; Wang, X.; Guan; Raja, S.N.; Woodbury, C.J.; Basbaum, A.I.; Edwards, R.H. (2009). "Low threshold C-mechanoreceptors are required for injury-induced mechanical hypersensitivity". Nature 462: 651–655. doi:10.1038/nature08505.
• Scherrer, G.; Low, S.A.; Wang, X.; Zhang, J.; Yamanaka, H.; Urban, R. Solorano; Harper, B.; Hnasko, T.S.; Edwards, R.H.; Basbaum, A.I. (Dec 2010). "VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity". Proc Natl Acad Sci USA 107 (51): 22296–301. doi:10.1073/pnas.1013413108. PMC 3009833. PMID 21135246.
• Shields, S.D.; Cavanaugh, D.J.; Lee, H.; Anderson, D.J.; Basbaum, A.I. (Nov 2010). "Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors". Pain 151 (2): 422–9. doi:10.1016/j.pain.2010.08.001. PMC 2955806. PMID 20832171.

References

1. http://anatomy.ucsf.edu/BasbaumFaculty6.html
2. http://bms.ucsf.edu/directory/faculty/allan-basbaum-phd
3. http://www.iasp-pain.org/AM/Template.cfm?Section=Councilors&Template=/CM/HTMLDisplay.cfm&ContentID=2130

External links

• http://www.nationalpainfoundation.org/articles/893/pioneers-in-pain-medicine