Alpha-lytic endopeptidase

Identifiers

Databases

IntEnz

IntEnz view

PDB structures

Search
PMC	articles
PubMed	articles
NCBI	proteins

Alpha-lytic endopeptidase (EC 3.4.21.12, myxobacter alpha-lytic proteinase, alpha-lytic proteinase, alpha-lytic protease, Mycobacterium sorangium alpha-lytic proteinase, Myxobacter 495 alpha-lytic proteinase) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Preferential cleavage: Ala-, Val- in bacterial cell walls, elastin and other proteins

This enzyme is isolated from the myxobacterium Lysobacter enzymogenes.

References

↑ Olson, M.O.J., Nagabushan, N., Dzwiniel, M., Smillie, L.B. and Whitaker, D.R. (1970). "Primary structure of α-lytic protease: a bacterial homologue of the pancreatic serine proteases". Nature 228: 438–442. doi:10.1038/228438a0. PMID 5482494.
↑ Polgár, L. (1987). "Structure and function of serine proteases". In Neuberger, A. and Brocklehurst, K. New Comprehensive Biochemistry: Hydrolytic Enzymes 16. Amsterdam: Elsevier. pp. 159–200.
↑ Epstein, D.M. and Wensink, P.C. (1988). "The α-lytic protease gene of Lysobacter enzymogenes. The nucleotide sequence predicts a large prepro-peptide with homology to pro-peptides of other chymotrypsin-like enzymes". J. Biol. Chem. 263: 16586–16590. PMID 3053694.
↑ Bone, R., Frank, D., Kettner, C.A. and Agard, D.A. (1989). "Structural analysis of specificity: α-lytic protease complexes with analogues of reaction intermediates". Biochemistry 28: 7600–7609. doi:10.1021/bi00445a015. PMID 2611204.

External links

Alpha-lytic endopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)

Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic

Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator

Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase

Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin

Venombin	Ancrod Batroxobin

Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin Streptokinase S1P Cathepsin A G

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

This article is issued from Wikipedia - version of the Monday, January 25, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.