Amikhelline

Amikhelline
Systematic (IUPAC) name

9-(2-diethylaminoethoxy)-4-hydroxy-7-methylpyrano[3,2-f][1]benzoxol-5-one
Pharmacokinetic data
Metabolism	none
Identifiers
CAS Number	4439-67-2^Y
ATC code	none
PubChem	CID 71198
ChemSpider	64334^Y
UNII	BD9T227F6M^Y
ChEMBL	CHEMBL2104025
Chemical data
Formula	C₁₈H₂₁NO₅
Molar mass	331.363 g/mol
SMILES O=C/1c3c(O\C(=C\1)C)c(OCCN(CC)CC)c2occc2c3O
InChI InChI=1S/C18H21NO5/c1-4-19(5-2)7-9-23-18-16-12(6-8-22-16)15(21)14-13(20)10-11(3)24-17(14)18/h6,8,10,21H,4-5,7,9H2,1-3H3^Y Key:QZBPFSZZMYTRIA-UHFFFAOYSA-N^Y
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Amikhelline is an antimitotic drug.^[1] It acts as a DNA intercalator^[2] and inhibits DNA polymerase.^[3]

References

↑ Turchini MF, Geneix A, Perissel B, Malet P, Turchini JP. Characterization of chromosomal aberrations induced in man by various antimitotic agents. (French). Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales. 1985;179(3):331-9. PMID 2417673
↑ Rucheton M, Jeanteur P. Studies on amikhellin. I. Intercalative binding to double-stranded DNA. Biochimie. 1973;55(11):1415-20. PMID 4364376
↑ Rucheton M, Jeanteur P. Studies on amikhellin. II.-Inhibition of dna-polymerase from murine sarcoma leukemia virus. Biochimie. 1976;58(6):689-95. PMID 60141

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