Andreas Pfaltz

Andreas Pfaltz
Born (1948-05-10) 10 May 1948
Basel, Switzerland
Nationality Swiss
Fields Chemistry
Institutions University of Basel
Max Planck Institute for Coal Research
ETH Zurich
Alma mater ETH Zurich
Thesis  (1978)
Doctoral advisor Prof. Albert Eschenmoser
Known for chiral ligands, coordination chemistry and catalysis
Notable awards Pracejus Prize (2003)
Prelog Medal (2003)
Ryoji Noyori Prize (2008)
Website
www.chemie.unibas.ch/~pfaltz/index.html

Andreas Pfaltz (born 10 May 1948) is a Swiss chemist known for his work in the area of coordination chemistry and catalysis.

Education and professional life

Andreas Pfaltz studied at ETH Zurich, completing his undergraduate Diploma in Natural Sciences in 1972 and his PhD in Organic Chemistry in 1978. His doctoral supervisor was Albert Eschenmoser, whose research into vitamin B12 and other corrin rings would influence Pfaltz's early research.[1] Following a two year postdoctoral position at Columbia University (early 1978 - late 1979), working for Gilbert Stork on the synthesis of Rifamycin,[2] he returned to ETH Zurich as a lecturer and began his own research. In 1990 he was appointed as an associate Professor at the University of Basel, becoming a full Professor in 1993. Between 1995 and 1998 he was a director of the prestigious Max Planck Institute for Coal Research, afterwards returning to the University of Basel, where he has remained till the present day.

Research

Pfaltz's early research was influenced by his PhD supervisor Albert Eschenmoser and was largely based around the synthesis of corrins,[3] porphyrins[4] and other macrocycles. During the second half of the 1980s he began to use fragments of these macrocycles as novel ligands for asymmetric catalysis, with chiral C2-symmetric semicorrins being the most successful example.[5][6] Following the development of structurally related bis(oxazoline)s Pfaltz began using and developing various oxazoline based ligands, making significant contributions to the known chemistry of phosphinooxazolines.[7][8] His current research activities remain focused on ligand development, asymmetric catalysis and catalyst screening.

Professional appointments

Awards

References

  1. Pfaltz, Andreas (1999). "From Corrin Chemistry to Asymmetric Catalysis - A Personal Account". Synlett (S1): 835–842. doi:10.1055/s-1999-3122.
  2. Helmchen, Günter (5 May 2008). "Andreas Pfaltz: on the Occasion of his 60th Birthday". Advanced Synthesis & Catalysis 350 (7-8): 951–952. doi:10.1002/adsc.200800113.
  3. Rasetti, Vittorio; Hilpert, Kurt; Fässler, Alexander; Pfaltz, Andreas; Eschenmoser, Albert (1 December 1981). "The Dihydrocorphinol→ Corrin Ring Contraction: A Potentially Biomimetic Mode of Formation of the Corrin Structure". Angewandte Chemie International Edition in English 20 (12): 1058–1060. doi:10.1002/anie.198110581.
  4. Pfaltz, Andreas; Jaun, Bernhard; Fassler, Alexander; Eschenmoser, Albert; Jaenchen, Rolf; Gilles, Hans Harald; Diekert, Gabriele; Thauer, Rudolf K. (5 May 1982). "Zur Kenntnis des Faktors F430 aus methanogenen Bakterien: Struktur des porphinoiden Ligandsystems". Helvetica Chimica Acta 65 (3): 828–865. doi:10.1002/hlca.19820650320.
  5. Fritschi, Hugo; Leutenegger, Urs; Pfaltz, Andreas (1 November 1986). "Chiral Copper-Semicorrin Complexes as Enantioselective Catalysts for the Cyclopropanation of Olefins by Diazo Compounds". Angewandte Chemie International Edition in English 25 (11): 1005–1006. doi:10.1002/anie.198610051.
  6. Pfaltz, Andreas (1 June 1993). "Chiral semicorrins and related nitrogen heterocycles as ligands in asymmetric catalysis". Accounts of Chemical Research 26 (6): 339–345. doi:10.1021/ar00030a007.
  7. Helmchen, Günter; Pfaltz, Andreas. "PhosphinooxazolinesA New Class of Versatile, Modular P,N-Ligands for Asymmetric Catalysis". Accounts of Chemical Research 33 (6): 336–345. doi:10.1021/ar9900865. PMID 10891051.
  8. von Matt, Peter; Pfaltz, Andreas (1 April 1993). "Chiral Phosphinoaryldihydrooxazoles as Ligands in Asymmetric Catalysis: Pd-Catalyzed Allylic Substitution". Angewandte Chemie International Edition in English 32 (4): 566–568. doi:10.1002/anie.199305661.
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