Annamycin

Annamycin

Systematic (IUPAC) name
(7S,9S)-7-[(2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo- 6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9- (2-hydroxyacetyl)-8,10-dihydro-7H-tetracene-5,12-dione
Identifiers
CAS Number	92689-49-1
ATC code	none
PubChem	CID 115212
ChemSpider	103088
UNII	SNU299M83Q
Chemical data
Formula	C26H25IO11
Molar mass	640.375 g/mol
SMILES O=C2c1c(O)c5c(c(O)c1C(=O)c3ccccc23)C[C@@](O)(C(=O)CO)C[C@@H]5O[C@@H]4O[C@H]([C@H](O)[C@@H](O)[C@H]4I)C
InChI InChI=1S/C26H25IO11/c1-9-19(30)24(35)18(27)25(37-9)38-13-7-26(36,14(29)8-28)6-12-15(13)23(34)17-16(22(12)33)20(31)10-4-2-3-5-11(10)21(17)32/h2-5,9,13,18-19,24-25,28,30,33-36H,6-8H2,1H3/t9-,13-,18+,19-,24-,25-,26-/m0/s1 Key:CIDNKDMVSINJCG-GKXONYSUSA-N
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Annamycin is an anthracycline antibiotic being investigated for the treatment of cancer.

Further reading

• Priebe W (1995). "Mechanism of action-governed design of anthracycline antibiotics: a "turn-off/turn-on" approach". Current Pharmaceutical Design 1 (1): 51–68.
• Trevino AV, Woynarowska BA, Herman TS, Priebe W, Woynarowski JM (November 2004). "Enhanced topoisomerase II targeting by annamycin and related 4-demethoxy anthracycline analogues". Mol Cancer Ther 3 (11): 1403–10. PMID 15542779.

External links

• National Cancer Institute Definition of Annamycin