Ap4A

Diadenosine tetraphosphate or Ap4A is a putative alarmone, ubiquitous in nature being common to everything from bacteria to humans. Adenosine polyphosphates are capable of inducing multiple physiological effects.[1] The molecule's role as a second messenger has recently been discovered in The LysRS-Ap4A-MITF signaling pathway.[2]

References

  1. ↑
    • Luo J, Jankowski V, Güngär N, Neumann J, Schmitz W, Zidek W, Schlüter H, Jankowski J. (2004). "Endogenous diadenosine tetraphosphate, diadenosine pentaphosphate, and diadenosine hexaphosphate in human myocardial tissue.". Hypertension 43 (5): 1055–9. doi:10.1161/01.hyp.0000126110.46402.dd. PMID 15066958.
  2. ↑
    • Lee YN, Nechushtan H, Figov N, Razin E (April 2004). "The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells.". Immunity 20 (2): 145–51. doi:10.1016/S1074-7613(04)00020-2. PMID 14975237.


This article is issued from Wikipedia - version of the Saturday, April 12, 2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.