Archaeosine synthase

Archaeosine synthase (EC 2.6.1.97, ArcS, TgtA2, MJ1022 (gene), glutamine:preQ0-tRNA amidinotransferase) is an enzyme with systematic name L-glutamine:7-cyano-7-carbaguanine aminotransferase.^[1]^[2] This enzyme catalyses the following chemical reaction

L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O

\rightleftharpoons

L-glutamate + archaeine¹⁵ in tRNA

In Euryarchaeota the reaction is catalysed by ArcS.

References

↑ Phillips, G., Chikwana, V.M., Maxwell, A., El-Yacoubi, B., Swairjo, M.A., Iwata-Reuyl, D. and de Crecy-Lagard, V. (2010). "Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA". J. Biol. Chem. 285: 12706–12713. doi:10.1074/jbc.M110.102236. PMC 2857094. PMID 20129918.
↑ Phillips, G., Swairjo, M.A., Gaston, K.W., Bailly, M., Limbach, P.A., Iwata-Reuyl, D. and de Crecy-Lagard, V. (2012). "Diversity of archaeosine synthesis in crenarchaeota". ACS Chem. Biol. 7 (2): 300–305. doi:10.1021/cb200361w. PMID 22032275.

External links

Archaeosine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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