Artesunate/amodiaquine
| Combination of | |
|---|---|
| Artesunate | Antimalarial |
| Amodiaquine | Antimalarial |
| Clinical data | |
| Trade names | Coarsucam |
| Pregnancy category |
|
| Identifiers | |
| CAS Number |
944945-14-6  |
| ATC code | P01BF03 |
| ChemSpider | none |
 (what is this?) (verify) | |
Artesunate/amodiaquine (trade name Coarsucam) is a fixed-dose artemisinin-based combination therapy (ACT) indicated for the treatment of acute uncomplicated Plasmodium falciparum malaria.
Early clinical trials showed that a once-a-day dosage was effective.[1] It was subsequently clinically shown to be equally effective as artemether/lumefantrine ("Coartem"),[2] although it is likely to be more effective in the field due to its simpler once-a-day dosage compared to artemether/lumefantrine twice-per-day dosage.
It was launched in 2007 as an affordable treatment for malaria, devised by DNDi in partnership with Sanofi-Aventis.[3] The drug is patent free.[4]
It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[5]
References
- ↑ Ndiaye, Jean; Randrianarivelojosia, Milijaona; Sagara, Issaka; Brasseur, Philippe; Ndiaye, Ibrahima; Faye, Babacar; Randrianasolo, Laurence; Ratsimbasoa, Arsène; Forlemu, Doris; Moor, Vicky; Traore, Aminata; Dicko, Yahia; Dara, Niawanlou; Lameyre, Valérie; Diallo, Mouctar; Djimde, Abdoulaye; Same-Ekobo, Albert; Gaye, Oumar (June 2009). "Randomized, multicentre assessment of the efficacy and safety of ASAQ – a fixed-dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria". Malaria Journal 8: 125. doi:10.1186/1475-2875-8-125. PMC 2698916. PMID 19505304. Retrieved 18 January 2013.
- ↑ Nidiaye, Jean-Louis A; Faye, Babacar; Gueye, Ali; Tine, Roger; Ndiaye, Daouda; Tchania, Corinne; Ndiaye, Ibrahima; Barry, Aichatou; Cissé, Badara; Lameyre, Valérie; Gaye, Oumar (2011). "Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial". Malaria Journal 10: 237. doi:10.1186/1475-2875-10-237. PMC 3171378. PMID 21838909. Retrieved 18 January 2013.
- ↑ "New, Once-a-Day Fixed-Dose Combination Against Malaria Now Available". 080218 dndi.org
- ↑ "ASAQ - The $1 Future of Malaria Treatment « GlobaLab". 080218 globalab.wordpress.com
- ↑ "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Retrieved May 10, 2015.