MAGI2

Membrane associated guanylate kinase, WW and PDZ domain containing 2
PDB rendering based on 1uep.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1UEP​, 1UEQ​, 1UEW​, 1UJV​, 1WFV​
Identifiers
Symbols	MAGI2 ; ACVRIP1; AIP-1; AIP1; ARIP1; MAGI-2; SSCAM
External IDs	OMIM: 606382 MGI: 1354953 HomoloGene: 8189 GeneCards: MAGI2 Gene
Gene ontology Molecular function • signal transducer activity • protein binding • phosphatase binding • receptor signaling complex scaffold activity • beta-1 adrenergic receptor binding • SMAD binding • type II activin receptor binding Cellular component • nucleus • cytoplasm • late endosome • plasma membrane • bicellular tight junction • postsynaptic density • dendrite • slit diaphragm • protein complex • synapse • perinuclear region of cytoplasm Biological process • positive regulation of receptor internalization • planar cell polarity pathway involved in axis elongation • negative regulation of cell proliferation • positive regulation of neuron projection development • cytoplasmic transport • negative regulation of cell migration • positive regulation of phosphoprotein phosphatase activity • negative regulation of activin receptor signaling pathway • nerve growth factor signaling pathway • receptor clustering • protein heterooligomerization • negative regulation of protein kinase B signaling • SMAD protein signal transduction • mitotic cell cycle arrest • glomerular visceral epithelial cell development • neuroligin clustering involved in postsynaptic membrane assembly • cellular response to nerve growth factor stimulus • positive regulation of synaptic vesicle clustering Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9863	50791
Ensembl	ENSG00000187391	ENSMUSG00000040003
UniProt	Q86UL8	Q9WVQ1
RefSeq (mRNA)	NM_001301128	NM_001170745
RefSeq (protein)	NP_001288057	NP_001164216
Location (UCSC)	Chr 7: 78.02 – 79.45 Mb	Chr 5: 19.23 – 20.7 Mb
PubMed search

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an enzyme that in humans is encoded by the MAGI2 gene.^[1][2][3]

Function

The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.^[3]

Interactions

MAGI2 has been shown to interact with ATN1^[4] and PTEN (gene).

References

1. Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H (Mar 2000). "Identification and characterization of a PDZ protein that interacts with activin type II receptors". J Biol Chem 275 (8): 5485–92. doi:10.1074/jbc.275.8.5485. PMID 10681527.
2. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
3. "Entrez Gene: MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2".
4. Wood, J D; Yuan J; Margolis R L; Colomer V; Duan K; Kushi J; Kaminsky Z; Kleiderlein J J; Sharp A H; Ross C A (Jun 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol. Cell. Neurosci. (UNITED STATES) 11 (3): 149–60. doi:10.1006/mcne.1998.0677. ISSN 1044-7431. PMID 9647693.

Further reading

• Wood JD, Yuan J, Margolis RL, et al. (1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.". Mol. Cell. Neurosci. 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
• "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Ide N, Hata Y, Deguchi M, et al. (1999). "Interaction of S-SCAM with neural plakophilin-related Armadillo-repeat protein/delta-catenin.". Biochem. Biophys. Res. Commun. 256 (3): 456–61. doi:10.1006/bbrc.1999.0364. PMID 10080919.
• Wu X, Hepner K, Castelino-Prabhu S, et al. (2000). "Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4233–8. doi:10.1073/pnas.97.8.4233. PMC 18208. PMID 10760291.
• Xu J, Paquet M, Lau AG, et al. (2001). "beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.". J. Biol. Chem. 276 (44): 41310–7. doi:10.1074/jbc.M107480200. PMID 11526121.
• Vazquez F, Grossman SR, Takahashi Y, et al. (2002). "Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex.". J. Biol. Chem. 276 (52): 48627–30. doi:10.1074/jbc.C100556200. PMID 11707428.
• Nishimura W, Yao I, Iida J, et al. (2002). "Interaction of synaptic scaffolding molecule and Beta -catenin.". J. Neurosci. 22 (3): 757–65. PMID 11826105.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yap CC, Muto Y, Kishida H, et al. (2003). "PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein.". Biochem. Biophys. Res. Commun. 301 (4): 1122–8. doi:10.1016/S0006-291X(03)00070-6. PMID 12589829.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Evgrafov OV, Mersiyanova I, Irobi J, et al. (2004). "Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.". Nat. Genet. 36 (6): 602–6. doi:10.1038/ng1354. PMID 15122254.
• Franklin JL, Yoshiura K, Dempsey PJ, et al. (2005). "Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein.". Exp. Cell Res. 303 (2): 457–70. doi:10.1016/j.yexcr.2004.10.007. PMID 15652357.
• Hu Y, Li Z, Guo L, et al. (2007). "MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells.". Arch. Biochem. Biophys. 467 (1): 1–9. doi:10.1016/j.abb.2007.07.027. PMID 17880912.