Augustus d'Este

Sir Augustus d'Este
KCH
Born Augustus Frederick Hanover
(1794-01-13)13 January 1794
London, Great Britain
Died 28 December 1848(1848-12-28) (aged 54)
Ramsgate, Kent
Parent(s) Prince Augustus Frederick, Duke of Sussex
Lady Augusta Murray

Sir Augustus Frederick d'Este, KCH (1794–1848) was the son of Prince Augustus Frederick, Duke of Sussex, and Lady Augusta Murray, and the grandson of George III. His parents' marriage was in contravention of the Royal Marriages Act 1772 and thus legally null and void. Therefore, Augustus d'Este was illegitimate for purposes of British law. He was born Augustus Frederick Hanover, but the last name was later legally changed to d'Este.

An active member of the Aborigines Protection Society particularly interested in Native Americans he gave considerable assistance to Peter Jones, the Mississauga missionary and leader to argue for title to their lands in Upper Canada.[1]

Augustus d'Este is the earliest recorded person for whom a definite diagnosis of multiple sclerosis can be made.[2][3][4] The course of his MS, which was not diagnosed during his lifetime, is known from the diaries he kept. D'Este left a detailed diary describing his 22 years living with the disease. He began his diary in 1822 and it had its last entry in 1846; only to remain unknown until 1948.[5]

His symptoms began at age 28 with a sudden transient visual loss after the funeral of a friend. During the course of his disease he developed weakness of the legs, clumsiness of the hands, numbness, dizziness, bladder disturbances, and erectile dysfunction. By 1843 he was experiencing persistent symptoms including tremor and nocturnal spasms, and in 1844 he began to use a wheelchair. In his last years he was confined to his bed. Despite his illness, he kept an optimistic view of life.

External links

References

  1. ↑ K. D. Reynolds, 'D'Este, Sir Augustus Frederick (1794–1848)', Oxford Dictionary of National Biography, Oxford University Press, 2004
  2. ↑ Alastair Compston; et al. (2005), McAlpine's Multiple Sclerosis 4th ed., Churchill Livingstone
  3. ↑ Landtblom, Anne-Marie; Fazio Patrik; Fredrikson Sten; Granieri Enrico (Feb 2010). "The first case history of multiple sclerosis: Augustus d'Este (1794–1848)". Neurol. Sci. (Italy) 31 (1): 29–33. doi:10.1007/s10072-009-0161-4. PMID 19838623.
  4. ↑ Landtblom, Anne-Marie; Granieri Enrico; Fredrikson Sten (2007). "Augustus d'Este—the first documented case of MS". Lakartidningen (in Swedish) (Sweden) 104 (26–27): 2009–11. ISSN 0023-7205. PMID 17639800.
  5. ↑ Firth, D (1948). The Case of August D'Esté. Cambridge: Cambridge University Press.
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