B3GNT1

Beta-1,4-glucuronyltransferase 1
Identifiers
Symbols	B4GAT1 ; B3GN-T1; B3GNT1; B3GNT6; BETA3GNTI; MDDGA13; iGAT; iGNT
External IDs	OMIM: 605517 MGI: 1919680 HomoloGene: 38239 GeneCards: B4GAT1 Gene
EC number	2.4.1.149
Gene ontology Molecular function • N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity • glucuronosyltransferase activity • metal ion binding Cellular component • Golgi membrane • Golgi apparatus • integral component of Golgi membrane • extracellular exosome Biological process • carbohydrate metabolic process • axon guidance • keratan sulfate biosynthetic process • glycosaminoglycan metabolic process • poly-N-acetyllactosamine biosynthetic process • protein O-linked mannosylation • keratan sulfate metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11041	108902
Ensembl	ENSG00000174684	ENSMUSG00000047379
UniProt	O43505	Q8BWP8
RefSeq (mRNA)	NM_006876	NM_175383
RefSeq (protein)	NP_006867	NP_780592
Location (UCSC)	Chr 11: 66.35 – 66.35 Mb	Chr 19: 5.04 – 5.04 Mb
PubMed search

N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the B3GNT1 gene.^[1][2]

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It is essential for the synthesis of poly-N-acetyllactosamine, a determinant for the blood group i antigen.^[2]

References

1. Sasaki K, Kurata-Miura K, Ujita M, Angata K, Nakagawa S, Sekine S, Nishi T, Fukuda M (Feb 1998). "Expression cloning of cDNA encoding a human β-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis". Proc Natl Acad Sci U S A 94 (26): 14294–9. doi:10.1073/pnas.94.26.14294. PMC 24948. PMID 9405606.
2. "Entrez Gene: B3GNT1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.