BACE1-AS

BACE1 antisense RNA
Identifiers
Symbols	BACE1-AS ; BACE1-AS1; BACE1AS; NCRNA00177
External IDs	OMIM: 614263 GeneCards: BACE1-AS Gene
Gene ontology
Orthologs
Species	Human	Mouse
Entrez	100379571	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	Chr 11: 117.29 – 117.29 Mb	n/a
PubMed search		n/a

BACE1-AS, also known as BACE1 antisense RNA (non-protein coding), is a human gene at 11q23.3 encoding a long noncoding RNA molecule. It is transcribed from the opposite strand to BACE1 and is upregulated in patients with Alzheimer's disease.^[1] BACE1-AS regulates the expression of BACE1 by increasing BACE1 mRNA stability and generating additional BACE1 through a post-transcriptional feed-forward mechanism. By the same mechanism it also raises concentrations of beta amyloid, the main constituent of senile plaques. BACE1-AS concentrations are elevated in subjects with Alzheimer's disease and in amyloid precursor protein transgenic mice.

Knocking down BACE1-AS reduces amyloid production and plaque deposition.^[2]

References

1. Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, Kenny PJ, Wahlestedt C (2008). "Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase". Nat Med 14 (7): 723–30. doi:10.1038/nm1784. PMC 2826895. PMID 18587408.
2. Modarresi F, Faghihi MA, Patel NS, Sahagan BG, Wahlestedt C, Lopez-Toledano MA. (2011). "Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis". Int J Alzheimers Dis 2011: 929042. doi:10.4061/2011/929042. PMC 3139208. PMID 21785702.