BAG5

BCL2-associated athanogene 5
PDB rendering based on 1ugo.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2D9D​, 3A8Y​
Identifiers
Symbols	BAG5 ; BAG-5
External IDs	OMIM: 603885 MGI: 1917619 HomoloGene: 3584 GeneCards: BAG5 Gene
Gene ontology Molecular function • protein binding • protein kinase binding • ubiquitin protein ligase binding • chaperone binding Cellular component • nucleus • mitochondrion • cytosol • membrane • inclusion body • perinuclear region of cytoplasm Biological process • protein folding • negative regulation of protein ubiquitination • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • cellular response to heat • regulation of ubiquitin-protein transferase activity • negative regulation of ubiquitin-protein transferase activity • negative regulation of protein refolding • neuron death • regulation of inclusion body assembly • regulation of cellular response to heat • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9529	70369
Ensembl	ENSG00000166170	ENSMUSG00000049792
UniProt	Q9UL15	Q8CI32
RefSeq (mRNA)	NM_001015048	NM_027404
RefSeq (protein)	NP_001015048	NP_081680
Location (UCSC)	Chr 14: 103.56 – 103.56 Mb	Chr 12: 111.71 – 111.71 Mb
PubMed search

BAG family molecular chaperone regulator 5 is a protein that in humans is encoded by the BAG5 gene.^[1][2][3]

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.^[3]

References

1. Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J Biol Chem 274 (2): 781–6. doi:10.1074/jbc.274.2.781. PMID 9873016.
2. Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (Dec 2004). "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration". Neuron 44 (6): 931–45. doi:10.1016/j.neuron.2004.11.026. PMID 15603737.
3. "Entrez Gene: BAG5 BCL2-associated athanogene 5".

Further reading

• Takayama S, Sato T, Krajewski S; et al. (1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell 80 (2): 279–84. doi:10.1016/0092-8674(95)90410-7. PMID 7834747.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Höhfeld J, Jentsch S (1997). "GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1". EMBO J. 16 (20): 6209–16. doi:10.1093/emboj/16.20.6209. PMC 1326305. PMID 9321400.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Nagase T, Ishikawa K, Suyama M; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.