BAPTA

BAPTA

Names
IUPAC name 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid
Identifiers
CAS Number	85233-19-8
ChEBI	CHEBI:60888
ChemSpider	94562
Jmol interactive 3D	Image
PubChem	104751
InChI InChI=1S/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32) Key: FTEDXVNDVHYDQW-UHFFFAOYSA-N InChI=1/C22H24N2O10/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32) Key: FTEDXVNDVHYDQW-UHFFFAOYAD
SMILES O=C(O)CN(c2ccccc2OCCOc1ccccc1N(CC(=O)O)CC(=O)O)CC(=O)O
Properties
Chemical formula	C22H24N2O10
Molar mass	476.433
Density	1.494 g/cm^3
Melting point	177 to 179 °C (351 to 354 °F; 450 to 452 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

BAPTA (1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid) is a calcium-specific aminopolycarboxylic acid. The presence of four carboxylic acid functional groups makes possible the binding of two calcium ions. The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium and other metal ions.

There is a range of reported values for the dissociation constant of BAPTA, though 0.2 µM appears consistently.^[1] The rate constant for calcium binding is 500 µM⁻¹ s⁻¹.^[1]

See also

• EDTA
• EGTA
• Fura-2

References

1. Ricci AJ, Wu YC, Fettiplace R (15 October 1998). "The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells.". The Journal of Neuroscience 18 (20): 8261–77. PMID 9763471.