HLA-B associated transcript 3

BCL2-associated athanogene 6
PDB rendering based on 1wx9.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1WX9​, 4DWF​, 4EEW​, 4WWR​, 4X86​
Identifiers
Symbols	BAG6 ; BAG-6; BAT3; D6S52E; G3
External IDs	OMIM: 142590 MGI: 1919439 HomoloGene: 3409 GeneCards: BAG6 Gene
Gene ontology Molecular function • protein binding • Hsp70 protein binding • polyubiquitin binding • ubiquitin protein ligase binding • ribosome binding • misfolded protein binding • proteasome binding • ubiquitin-specific protease binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol • membrane • intracellular membrane-bounded organelle • BAT3 complex Biological process • kidney development • immune system process • ubiquitin-dependent protein catabolic process • transport • synaptonemal complex assembly • spermatogenesis • brain development • embryo development • chromatin modification • internal peptidyl-lysine acetylation • cell differentiation • lung development • negative regulation of proteasomal ubiquitin-dependent protein catabolic process • regulation of cell proliferation • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • negative regulation of apoptotic process • negative regulation of proteolysis • protein stabilization • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • tail-anchored membrane protein insertion into ER membrane • positive regulation of ERAD pathway • maintenance of unfolded protein involved in ERAD pathway • protein localization to cytosolic proteasome complex involved in ERAD pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7917	224727
Ensembl	ENSG00000096155	ENSMUSG00000024392
UniProt	P46379	Q9Z1R2
RefSeq (mRNA)	NM_001098534	NM_001252468
RefSeq (protein)	NP_001092004	NP_001239397
Location (UCSC)	Chr 6: 31.64 – 31.65 Mb	Chr 17: 35.14 – 35.15 Mb
PubMed search

Large proline-rich protein BAT3 is a protein that in humans is encoded by the BAT3 gene.^[1][2]

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is a nuclear protein. It has been implicated in the control of apoptosis and regulating heat shock protein. There are three alternatively spliced transcript variants described for this gene.^[2]

References

1. Banerji J, Sands J, Strominger JL, Spies T (Apr 1990). "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain". Proc Natl Acad Sci U S A 87 (6): 2374–8. doi:10.1073/pnas.87.6.2374. PMC 53689. PMID 2156268.
2. "Entrez Gene: BAT3 HLA-B associated transcript 3".

Further reading

• Takayama S, Reed JC (2001). "Molecular chaperone targeting and regulation by BAG family proteins". Nat. Cell Biol. 3 (10): E237–41. doi:10.1038/ncb1001-e237. PMID 11584289.
• Cross SJ, Tonks S, Trowsdale J, Campbell RD (1992). "Novel detection of restriction fragment length polymorphisms in the human major histocompatibility complex". Immunogenetics 34 (6): 376–84. doi:10.1007/BF01787488. PMID 1684176.
• Spies T, Bresnahan M, Strominger JL (1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8955–8. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.
• Spies T, Blanck G, Bresnahan M, et al. (1989). "A new cluster of genes within the human major histocompatibility complex". Science 243 (4888): 214–7. doi:10.1126/science.2911734. PMID 2911734.
• Ozaki T, Hanaoka E, Naka M, et al. (1999). "Cloning and characterization of rat BAT3 cDNA". DNA Cell Biol. 18 (6): 503–12. doi:10.1089/104454999315222. PMID 10390159.
• Thress K, Song J, Morimoto RI, Kornbluth S (2001). "Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper". EMBO J. 20 (5): 1033–41. doi:10.1093/emboj/20.5.1033. PMC 145500. PMID 11230127.
• Manchen ST, Hubberstey AV (2001). "Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis". Biochem. Biophys. Res. Commun. 287 (5): 1075–82. doi:10.1006/bbrc.2001.5701. PMID 11587531.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Wu YH, Shih SF, Lin JY (2004). "Ricin triggers apoptotic morphological changes through caspase-3 cleavage of BAT3". J. Biol. Chem. 279 (18): 19264–75. doi:10.1074/jbc.M307049200. PMID 14960581.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Kumar R, Lutz W, Frank E, Im HJ (2004). "Immediate early gene X-1 interacts with proteins that modulate apoptosis". Biochem. Biophys. Res. Commun. 323 (4): 1293–8. doi:10.1016/j.bbrc.2004.09.006. PMC 2895269. PMID 15451437.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.