BCL2L12

BCL2-like 12 (proline rich)
Identifiers
Symbols	BCL2L12 ; MGC120313; MGC120314; MGC120315
External IDs	OMIM: 610837 MGI: 1922986 HomoloGene: 12619 GeneCards: BCL2L12 Gene
Gene ontology Molecular function • p53 binding • protein binding Cellular component • nucleus • membrane Biological process • positive regulation of transcription from RNA polymerase II promoter • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • inhibition of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of cellular senescence Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83596	75736
Ensembl	ENSG00000126453	ENSMUSG00000003190
UniProt	Q9HB09	Q9D3J3
RefSeq (mRNA)	NM_001040668	NM_029410
RefSeq (protein)	NP_001035758	NP_083686
Location (UCSC)	Chr 19: 49.67 – 49.67 Mb	Chr 7: 44.99 – 45 Mb
PubMed search

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene.^[1][2]

The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[1]

Bcl2L12 expression is upregulated in most human glioblastomas. Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism.^[3] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.^[4]

References

1. "Entrez Gene: Bcl2L12 Bcl2-like 12 (proline rich)".
2. Scorilas A, Kyriakopoulou L, Yousef GM, Ashworth LK, Kwamie A, Diamandis EP (March 2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics 72 (2): 217–21. doi:10.1006/geno.2000.6455. PMID 11401436.
3. Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L (January 2007). "Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma". Genes Dev. 21 (1): 98–111. doi:10.1101/gad.1480007. PMC 1759904. PMID 17210792.
4. Wilson MR (August 1998). "Apoptosis: unmasking the executioner". Cell Death Differ. 5 (8): 646–52. doi:10.1038/sj.cdd.4400394. PMID 10200519.

Further reading

• Hammond PW, Alpin J, Rise CE; et al. (2001). "In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries". J. Biol. Chem. 276 (24): 20898–906. doi:10.1074/jbc.M011641200. PMID 11283018.
• Scorilas A, Kyriakopoulou L, Yousef GM; et al. (2001). "Molecular cloning, physical mapping, and expression analysis of a novel gene, BCL2L12, encoding a proline-rich protein with a highly conserved BH2 domain of the Bcl-2 family". Genomics 72 (2): 217–21. doi:10.1006/geno.2000.6455. PMID 11401436.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Talieri M, Diamandis EP, Katsaros N; et al. (2004). "Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors". Thromb. Haemost. 89 (6): 1081–8. doi:10.1267/THRO03061081. PMID 12783122.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mathioudaki K, Scorilas A, Papadokostopoulou A; et al. (2005). "Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer". Biol. Chem. 385 (9): 779–83. doi:10.1515/BC.2004.101. PMID 15493871.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.