BCLAF1

BCL2-associated transcription factor 1
Identifiers
Symbols	BCLAF1 ; BTF; bK211L9.1
External IDs	OMIM: 612588 MGI: 1917580 HomoloGene: 8832 GeneCards: BCLAF1 Gene
Gene ontology Molecular function • DNA binding • protein binding • poly(A) RNA binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm Biological process • transcription, DNA-templated • apoptotic process • positive regulation of apoptotic process • regulation of DNA-templated transcription in response to stress • negative regulation of transcription, DNA-templated • positive regulation of DNA-templated transcription, initiation • positive regulation of response to DNA damage stimulus • positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9774	72567
Ensembl	ENSG00000029363	ENSMUSG00000037608
UniProt	Q9NYF8	Q8K019
RefSeq (mRNA)	NM_001077440	NM_001025392
RefSeq (protein)	NP_001070908	NP_001020563
Location (UCSC)	Chr 6: 136.26 – 136.29 Mb	Chr 10: 20.31 – 20.34 Mb
PubMed search

Bcl-2-associated transcription factor 1 is a Bcl-2 family protein in humans that is encoded by the BCLAF1 gene.^[1][2][3]

This gene encodes a transcriptional repressor that interacts with several members of the BCL-2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different protein isoforms have been found for this gene.^[3]

References

1. Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
2. Kasof GM, Goyal L, White E (Jun 1999). "Btf, a Novel Death-Promoting Transcriptional Repressor That Interacts with Bcl-2-Related Proteins". Mol Cell Biol 19 (6): 4390–404. PMC 104398. PMID 10330179.
3. "Entrez Gene: BCLAF1 BCL2-associated transcription factor 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Haraguchi T, Holaska JM, Yamane M; et al. (2004). "Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy". Eur. J. Biochem. 271 (5): 1035–45. doi:10.1111/j.1432-1033.2004.04007.x. PMID 15009215.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zheng H, Hu P, Quinn DF, Wang YK (2005). "Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography". Mol. Cell Proteomics 4 (6): 721–30. doi:10.1074/mcp.M400077-MCP200. PMID 15659558.
• Mansharamani M, Wilson KL (2005). "Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor". J. Biol. Chem. 280 (14): 13863–70. doi:10.1074/jbc.M413020200. PMID 15681850.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Liu H, Lu ZG, Miki Y, Yoshida K (2007). "Protein Kinase C δ Induces Transcription of the TP53 Tumor Suppressor Gene by Controlling Death-Promoting Factor Btf in the Apoptotic Response to DNA Damage". Mol. Cell. Biol. 27 (24): 8480–91. doi:10.1128/MCB.01126-07. PMC 2169390. PMID 17938203.

External links

• FactorBook BCLAF1