BICD1

Bicaudal D homolog 1 (Drosophila)
Identifiers
Symbols	BICD1 ; BICD
External IDs	OMIM: 602204 MGI: 1101760 HomoloGene: 37518 GeneCards: BICD1 Gene
Gene ontology Molecular function • structural constituent of cytoskeleton • protein binding • cytoskeletal adaptor activity • Rab GTPase binding • proteinase activated receptor binding • dynactin binding • dynein binding Cellular component • Golgi apparatus • trans-Golgi network • cytosol • cytoskeleton • cytoplasmic microtubule • membrane • cytoplasmic vesicle • tubulin complex • perinuclear region of cytoplasm • host cell viral assembly compartment Biological process • RNA processing • intracellular mRNA localization • anatomical structure morphogenesis • viral process • protein localization to organelle • stress granule assembly • positive regulation of receptor-mediated endocytosis • minus-end-directed organelle transport along microtubule • microtubule anchoring at microtubule organizing center • negative regulation of phospholipase C activity • regulation of proteinase activated receptor activity • negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	636	12121
Ensembl	ENSG00000151746	ENSMUSG00000003452
UniProt	Q96G01	Q8BR07
RefSeq (mRNA)	NM_001003398	NM_001112796
RefSeq (protein)	NP_001003398	NP_001106267
Location (UCSC)	Chr 12: 32.11 – 32.38 Mb	Chr 6: 149.41 – 149.56 Mb
PubMed search

Protein bicaudal D homolog 1 is a protein that in humans is encoded by the BICD1 gene.^[1][2]

Function

This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.^[2]

Interactions

BICD1 has been shown to interact with RAB6A.^[3][4]

References

1. Baens M, Marynen P (Nov 1997). "A human homologue (BICD1) of the Drosophila bicaudal-D gene". Genomics 45 (3): 601–6. doi:10.1006/geno.1997.4971. PMID 9367685.
2. "Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)".
3. Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177.
4. Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (Dec 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383.

Further reading

• Barr FA, Short B (Aug 2003). "Golgins in the structure and dynamics of the Golgi apparatus". Current Opinion in Cell Biology 15 (4): 405–13. doi:10.1016/S0955-0674(03)00054-1. PMID 12892780. Check date values in: |year= / |date= mismatch (help)
• Claussen M, Suter B (Nov 2005). "BicD-dependent localization processes: from Drosophilia development to human cell biology". Annals of Anatomy - Anatomischer Anzeiger 187 (5-6): 539–53. doi:10.1016/j.aanat.2005.07.004. PMID 16320833. Check date values in: |year= / |date= mismatch (help)
• Baens M, Aerssens J, van Zand K, Van den Berghe H, Marynen P (Sep 1995). "Isolation and regional assignment of human chromosome 12p cDNAs". Genomics 29 (1): 44–52. doi:10.1006/geno.1995.1213. PMID 8530100. Check date values in: |year= / |date= mismatch (help)
• Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology 12 (20): 1792–5. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. Check date values in: |year= / |date= mismatch (help)
• Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (Dec 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. Check date values in: |year= / |date= mismatch (help)
• Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Fuchs E, Short B, Barr FA (2006). "Assay and properties of rab6 interaction with dynein-dynactin complexes". Methods in Enzymology 403: 607–18. doi:10.1016/S0076-6879(05)03053-3. PMID 16473624.
• Moorhead AR, Rzomp KA, Scidmore MA (Feb 2007). "The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner". Infection and Immunity 75 (2): 781–91. doi:10.1128/IAI.01447-06. PMC 1828475. PMID 17101644.
• Fumoto K, Hoogenraad CC, Kikuchi A (Dec 2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome". The EMBO Journal 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904. PMID 17139249. Check date values in: |year= / |date= mismatch (help)
• Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (Oct 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.