Bridging integrator 3

Bridging integrator 3
Identifiers
Symbols	BIN3 ; MGC14978
External IDs	OMIM: 606396 MGI: 1929883 HomoloGene: 5472 GeneCards: BIN3 Gene
Gene ontology Molecular function • protein binding • cytoskeletal adaptor activity Cellular component • cytoplasm • actin filament Biological process • cytokinesis • barrier septum assembly • actin filament organization • protein localization • unidimensional cell growth • regulation of lamellipodium assembly • myoblast migration involved in skeletal muscle regeneration • skeletal muscle fiber development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55909	57784
Ensembl	ENSG00000147439	ENSMUSG00000022089
UniProt	Q9NQY0	Q9JI08
RefSeq (mRNA)	NM_018688	NM_021328
RefSeq (protein)	NP_061158	NP_067303
Location (UCSC)	Chr 8: 22.62 – 22.67 Mb	Chr 14: 70.1 – 70.14 Mb
PubMed search

Bridging integrator 3 is a protein that in humans is encoded by the BIN3 gene.^[1][2]

Function

The product of this gene is a member of the BAR domain protein family. The encoded protein is composed solely of a BAR domain which is predicted to form coiled coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes.^[2]

References

1. Ren G, Vajjhala P, Lee JS, Winsor B, Munn AL (Mar 2006). "The BAR domain proteins: molding membranes in fission, fusion, and phagy". Microbiol Mol Biol Rev 70 (1): 37–120. doi:10.1128/MMBR.70.1.37-120.2006. PMC 1393252. PMID 16524918.
2. "Entrez Gene: BIN3 bridging integrator 3".

Further reading

• Habermann B (2004). "The BAR-domain family of proteins: a case of bending and binding?". EMBO Rep. 5 (3): 250–5. doi:10.1038/sj.embor.7400105. PMC 1299016. PMID 14993925.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Routhier EL, Burn TC, Abbaszade I; et al. (2001). "Human BIN3 complements the F-actin localization defects caused by loss of Hob3p, the fission yeast homolog of Rvs161p.". J. Biol. Chem. 276 (24): 21670–7. doi:10.1074/jbc.M101096200. PMID 11274158.