Baculoviral IAP repeat-containing protein 2

Baculoviral IAP repeat containing 2
PDB rendering based on 1qbh.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1QBH​, 2L9M​, 3D9T​, 3D9U​, 3M1D​, 3MUP​, 3OZ1​, 3T6P​, 3UW4​, 4EB9​, 4HY4​, 4HY5​, 4KMN​, 4LGE​, 4LGU​, 4MTI​, 4MU7​
Identifiers
Symbols	BIRC2 ; API1; HIAP2; Hiap-2; MIHB; RNF48; c-IAP1; cIAP1
External IDs	OMIM: 601712 MGI: 1197009 HomoloGene: 900 ChEMBL: 5462 GeneCards: BIRC2 Gene
Gene ontology Molecular function • transcription coactivator activity • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein N-terminus binding Cellular component • XY body • nucleus • cytoplasm • cytosol • spindle microtubule • cytoplasmic side of plasma membrane • CD40 receptor complex • membrane raft Biological process • protein polyubiquitination • response to hypoxia • placenta development • toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • transcription, DNA-templated • regulation of transcription, DNA-templated • apoptotic process • cellular component disassembly involved in execution phase of apoptosis • cell surface receptor signaling pathway • regulation of necrotic cell death • programmed cell death • regulation of toll-like receptor signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • TRIF-dependent toll-like receptor signaling pathway • NIK/NF-kappaB signaling • regulation of RIG-I signaling pathway • regulation of cell proliferation • regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of I-kappaB kinase/NF-kappaB signaling • proteasome-mediated ubiquitin-dependent protein catabolic process • innate immune response • regulation of innate immune response • response to ethanol • regulation of cell differentiation • regulation of inflammatory response • protein heterooligomerization • response to cAMP • regulation of cell cycle • regulation of necroptotic process • negative regulation of necroptotic process • necroptotic process • regulation of nucleotide-binding oligomerization domain containing signaling pathway • mitotic spindle assembly • programmed necrotic cell death • negative regulation of ripoptosome assembly involved in necroptotic process • positive regulation of protein K63-linked ubiquitination • positive regulation of protein K48-linked ubiquitination • positive regulation of protein monoubiquitination • inhibition of cysteine-type endopeptidase activity involved in apoptotic process • regulation of cysteine-type endopeptidase activity • regulation of reactive oxygen species metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	329	11797
Ensembl	ENSG00000110330	ENSMUSG00000057367
UniProt	Q13490	Q62210
RefSeq (mRNA)	NM_001166	NM_007465
RefSeq (protein)	NP_001157	NP_031491
Location (UCSC)	Chr 11: 102.35 – 102.38 Mb	Chr 9: 7.82 – 7.84 Mb
PubMed search

Baculoviral IAP repeat-containing protein 2 (also known as cIAP1) is a protein that in humans is encoded by the BIRC2 gene.^[1][2]

Function

cIAP1 is a member of the Inhibitor of Apoptosis family that inhibit apoptosis by interfering with the activation of caspases.

Interactions

BIRC2 has been shown to interact with:

• CASP9,^[3]
• DIABLO,^[4][5]
• GSPT1,^[4]
• HSP90B1,^[6]
• HTRA2,^[4][7]
• RIPK1,^[8]
• RIPK2^[9][10]
• TNFSF14,^[11]
• TRAF1,^[12][13][14]
• TRAF2,^{[12][13][14][15][16][17]} and
• UBC.^[6][8][18]

References

1. Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG (February 1996). "Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes". Nature 379 (6563): 349–53. doi:10.1038/379349a0. PMID 8552191.
2. Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV (February 1996). "The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins". Cell 83 (7): 1243–52. doi:10.1016/0092-8674(95)90149-3. PMID 8548810.
3. Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases". EMBO J. 17 (8): 2215–23. doi:10.1093/emboj/17.8.2215. PMC 1170566. PMID 9545235.
4. Hegde R, Srinivasula SM, Datta P, Madesh M, Wassell R, Zhang Z, Cheong N, Nejmeh J, Fernandes-Alnemri T, Hoshino S, Alnemri ES (2003). "The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein". J. Biol. Chem. 278 (40): 38699–706. doi:10.1074/jbc.M303179200. PMID 12865429.
5. Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL (2000). "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins". Cell 102 (1): 43–53. doi:10.1016/S0092-8674(00)00009-X. PMID 10929712.
6. Didelot C, Lanneau D, Brunet M, Bouchot A, Cartier J, Jacquel A, Ducoroy P, Cathelin S, Decologne N, Chiosis G, Dubrez-Daloz L, Solary E, Garrido C (2008). "Interaction of heat-shock protein 90 beta isoform (HSP90 beta) with cellular inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation". Cell Death Differ. 15 (5): 859–66. doi:10.1038/cdd.2008.5. PMID 18239673.
7. Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL (2002). "HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins". J. Biol. Chem. 277 (1): 445–54. doi:10.1074/jbc.M109891200. PMID 11604410.
8. Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J, Gillard JW, Jaquith JB, Morris SJ, Barker PA (2008). "cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination". Mol. Cell 30 (6): 689–700. doi:10.1016/j.molcel.2008.05.014. PMID 18570872.
9. McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. PMID 9642260.
10. Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, Tschopp J (1998). "Identification of CARDIAK, a RIP-like kinase that associates with caspase-1". Curr. Biol. 8 (15): 885–8. doi:10.1016/S0960-9822(07)00352-1. PMID 9705938.
11. Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL (2003). "Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis". J. Biol. Chem. 278 (16): 14363–9. doi:10.1074/jbc.M208672200. PMID 12571250.
12. Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1997). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases". EMBO J. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
13. Shu HB, Takeuchi M, Goeddel DV (1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. PMC 19479. PMID 8943045.
14. Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2". Nature 416 (6878): 345–7. doi:10.1038/416345a. PMID 11907583.
15. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
16. Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL (1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. doi:10.1073/pnas.93.10.4974. PMC 39390. PMID 8643514.
17. Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (2000). "Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein". J. Biol. Chem. 275 (15): 11114–20. doi:10.1074/jbc.275.15.11114. PMID 10753917.
18. Sekine K, Takubo K, Kikuchi R, Nishimoto M, Kitagawa M, Abe F, Nishikawa K, Tsuruo T, Naito M (2008). "Small molecules destabilize cIAP1 by activating auto-ubiquitylation". J. Biol. Chem. 283 (14): 8961–8. doi:10.1074/jbc.M709525200. PMID 18230607.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL (1996). "Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4974–8. doi:10.1073/pnas.93.10.4974. PMC 39390. PMID 8643514.
• Rajcan-Separovic E, Liston P, Lefebvre C, Korneluk RG (1997). "Assignment of human inhibitor of apoptosis protein (IAP) genes xiap, hiap-1, and hiap-2 to chromosomes Xq25 and 11q22-q23 by fluorescence in situ hybridization.". Genomics 37 (3): 404–6. doi:10.1006/geno.1996.0579. PMID 8938457.
• Shu HB, Takeuchi M, Goeddel DV (1997). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. PMC 19479. PMID 8943045.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC (1998). "The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases.". EMBO J. 16 (23): 6914–25. doi:10.1093/emboj/16.23.6914. PMC 1170295. PMID 9384571.
• Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC (1998). "IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.". EMBO J. 17 (8): 2215–23. doi:10.1093/emboj/17.8.2215. PMC 1170566. PMID 9545235.
• McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.". J. Biol. Chem. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. PMID 9642260.
• Young SS, Liston P, Xuan JY, McRoberts C, Lefebvre CA, Korneluk RG (1999). "Genomic organization and physical map of the human inhibitors of apoptosis: HIAP1 and HIAP2.". Mamm. Genome 10 (1): 44–8. doi:10.1007/s003359900940. PMID 9892732.
• Hinds MG, Norton RS, Vaux DL, Day CL (1999). "Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat.". Nat. Struct. Biol. 6 (7): 648–51. doi:10.1038/10701. PMID 10404221.
• Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL (2000). "Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.". Cell 102 (1): 43–53. doi:10.1016/S0092-8674(00)00009-X. PMID 10929712.
• Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM (2001). "ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas.". Curr. Biol. 10 (21): 1359–66. doi:10.1016/S0960-9822(00)00781-8. PMID 11084335.
• Werneburg BG, Zoog SJ, Dang TT, Kehry MR, Crute JJ (2001). "Molecular characterization of CD40 signaling intermediates.". J. Biol. Chem. 276 (46): 43334–42. doi:10.1074/jbc.M104994200. PMID 11562359.
• Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R (2001). "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.". Mol. Cell 8 (3): 613–21. doi:10.1016/S1097-2765(01)00341-0. PMID 11583623.
• Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL (2002). "HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.". J. Biol. Chem. 277 (1): 445–54. doi:10.1074/jbc.M109891200. PMID 11604410.
• Mellström B, Ceña V, Lamas M, Perales C, Gonzalez C, Naranjo JR (2002). "Gas1 is induced during and participates in excitotoxic neuronal death.". Mol. Cell. Neurosci. 19 (3): 417–29. doi:10.1006/mcne.2001.1092. PMID 11906213.
• Li X, Yang Y, Ashwell JD (2002). "TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.". Nature 416 (6878): 345–7. doi:10.1038/416345a. PMID 11907583.
• Imoto I, Tsuda H, Hirasawa A, Miura M, Sakamoto M, Hirohashi S, Inazawa J (2002). "Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy.". Cancer Res. 62 (17): 4860–6. PMID 12208731.