BMP2K
| BMP2 inducible kinase | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | BMP2K ; BIKE; HRIHFB2017 | ||||||||||||
| External IDs | MGI: 2155456 HomoloGene: 34134 ChEMBL: 4522 GeneCards: BMP2K Gene | ||||||||||||
| EC number | 2.7.11.1 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 55589 | 140780 | |||||||||||
| Ensembl | ENSG00000138756 | ENSMUSG00000034663 | |||||||||||
| UniProt | Q9NSY1 | Q91Z96 | |||||||||||
| RefSeq (mRNA) | NM_017593 | NM_080708 | |||||||||||
| RefSeq (protein) | NP_060063 | NP_542439 | |||||||||||
| Location (UCSC) |
Chr 4: 78.78 – 78.92 Mb |
Chr 5: 97 – 97.09 Mb | |||||||||||
| PubMed search | |||||||||||||
BMP-2-inducible protein kinase is an enzyme in humans encoded by the BMP2K gene.[1]
Function
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.[1]
References
Further reading
- Hoffmann A, Gross G (2002). "BMP signaling pathways in cartilage and bone formation". Critical Reviews in Eukaryotic Gene Expression 11 (1-3): 23–45. PMID 11693963.
- Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (Dec 1998). "Selection system for genes encoding nuclear-targeted proteins". Nature Biotechnology 16 (13): 1338–42. doi:10.1038/4315. PMID 9853615.
- Kearns AE, Donohue MM, Sanyal B, Demay MB (Nov 2001). "Cloning and characterization of a novel protein kinase that impairs osteoblast differentiation in vitro". The Journal of Biological Chemistry 276 (45): 42213–8. doi:10.1074/jbc.M106163200. PMID 11500515.
- Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Arikawa T, Omura K, Morita I (Sep 2004). "Regulation of bone morphogenetic protein-2 expression by endogenous prostaglandin E2 in human mesenchymal stem cells". Journal of Cellular Physiology 200 (3): 400–6. doi:10.1002/jcp.20031. PMID 15254968.
- Medici M, van Meurs JB, Rivadeneira F, Zhao H, Arp PP, Hofman A, Pols HA, Uitterlinden AG (Jun 2006). "BMP-2 gene polymorphisms and osteoporosis: the Rotterdam Study". Journal of Bone and Mineral Research 21 (6): 845–54. doi:10.1359/jbmr.060306. PMID 16753015.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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