BNC1

Basonuclin 1
Identifiers
Symbols	BNC1 ; BNC; BSN1; HsT19447
External IDs	OMIM: 601930 MGI: 1097164 HomoloGene: 31048 GeneCards: BNC1 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • metal ion binding Cellular component • nucleus • cytoplasm Biological process • transcription, DNA-templated • regulation of transcription from RNA polymerase I promoter • regulation of transcription from RNA polymerase II promoter • positive regulation of cell proliferation • epidermis development • wound healing • positive regulation of epithelial cell proliferation • chromosome organization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	646	12173
Ensembl	ENSG00000169594	ENSMUSG00000025105
UniProt	Q01954	O35914
RefSeq (mRNA)	NM_001301206	NM_007562
RefSeq (protein)	NP_001288135	NP_031588
Location (UCSC)	Chr 15: 83.26 – 83.28 Mb	Chr 7: 81.97 – 81.99 Mb
PubMed search

Zinc finger protein basonuclin-1 is a protein that in humans is encoded by the BNC1 gene.^[1][2]

The protein encoded by this gene is a zinc finger protein present in the basal cell layer of the epidermis and in hair follicles. It is also found in abundance in the germ cells of testis and ovary. This protein is thought to play a regulatory role in keratinocyte proliferation and it may also be a regulator for rRNA transcription. This gene seems to have multiple alternatively spliced transcript variants, but their full-length nature is not known yet. There seems to be evidence of multiple polyadenylation sites for this gene.^[2]

BNC1 or Basonuclin 1 does not interact with PICK1. This suggestion that is does is based on the article that proved that PICK1 interacts with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1). Both Basonuclin 1 and brain Na+ channel 1 have the same abbreviation BNC1, but they are not similar proteins and PICK1 interacts with the second protein, not the first one.

References

1. Tseng H, Green H (Dec 1992). "Basonuclin: a keratinocyte protein with multiple paired zinc fingers". Proc Natl Acad Sci U S A 89 (21): 10311–5. doi:10.1073/pnas.89.21.10311. PMC 50328. PMID 1332044.
2. "Entrez Gene: BNC1 basonuclin 1".

Further reading

• Tseng H (1998). "Basonuclin, a zinc finger protein associated with epithelial expansion and proliferation.". Front. Biosci. 3: D985–8. doi:10.2741/A338. PMID 9727087.
• Tseng H, Green H (1994). "Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.". J. Cell Biol. 126 (2): 495–506. doi:10.1083/jcb.126.2.495. PMC 2200026. PMID 8034748.
• Teumer J, Tseng H, Green H (1997). "The human basonuclin gene.". Gene 188 (1): 1–7. doi:10.1016/S0378-1119(96)00659-2. PMID 9099851.
• Yang Z, Gallicano GI, Yu QC, Fuchs E (1997). "An unexpected localization of basonuclin in the centrosome, mitochondria, and acrosome of developing spermatids.". J. Cell Biol. 137 (3): 657–69. doi:10.1083/jcb.137.3.657. PMC 2139879. PMID 9151672.
• Iuchi S, Green H (1997). "Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation.". Proc. Natl. Acad. Sci. U.S.A. 94 (15): 7948–53. doi:10.1073/pnas.94.15.7948. PMC 21535. PMID 9223293.
• Mahoney MG, Tang W, Xiang MM; et al. (1998). "Translocation of the zinc finger protein basonuclin from the mouse germ cell nucleus to the midpiece of the spermatozoon during spermiogenesis.". Biol. Reprod. 59 (2): 388–94. doi:10.1095/biolreprod59.2.388. PMID 9687312.
• Iuchi S, Green H (1999). "Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter.". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9628–32. doi:10.1073/pnas.96.17.9628. PMC 22260. PMID 10449744.
• Tseng H, Biegel JA, Brown RS (2000). "Basonuclin is associated with the ribosomal RNA genes on human keratinocyte mitotic chromosomes.". J. Cell. Sci. 112 Pt 18: 3039–47. PMID 10462520.
• Tang W, Tseng H (1999). "A GC-rich sequence within the 5' untranslated region of human basonuclin mRNA inhibits its translation.". Gene 237 (1): 35–44. doi:10.1016/S0378-1119(99)00299-1. PMID 10524234.
• Iuchi S, Easley K, Matsuzaki K; et al. (2000). "Alternative subcellular locations of keratinocyte basonuclin.". Exp. Dermatol. 9 (3): 178–84. doi:10.1034/j.1600-0625.2000.009003178.x. PMID 10839715.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Chen L, Willis SN, Wei A; et al. (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function.". Mol. Cell 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
• Vanhoutteghem A, Djian P (2006). "Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12423–8. doi:10.1073/pnas.0605086103. PMC 1567895. PMID 16891417.