BNIPL

BCL2/adenovirus E1B 19kD interacting protein like
Identifiers
Symbols	BNIPL ; BNIP-S; BNIPL-1; BNIPL-2; BNIPL1; BNIPL2; BNIPS; PP753
External IDs	OMIM: 611275 MGI: 2384749 HomoloGene: 15900 GeneCards: BNIPL Gene
Gene ontology Molecular function • protein binding • identical protein binding Cellular component • nucleus • cytosol Biological process • apoptotic process • negative regulation of cell proliferation • regulation of growth rate Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	149428	171388
Ensembl	ENSG00000163141	ENSMUSG00000028115
UniProt	Q7Z465	Q99JU7
RefSeq (mRNA)	NM_001159642	NM_001168356
RefSeq (protein)	NP_001153114	NP_001161828
Location (UCSC)	Chr 1: 151.04 – 151.05 Mb	Chr 3: 95.24 – 95.25 Mb
PubMed search

Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein is a protein that in humans is encoded by the BNIPL gene.^[1][2][3]

Interactions

BNIPL has been shown to interact with:

• BCL2-like 1,^[4][5]
• Bcl-2,^[4][5]
• CDC42,^[4]
• GFER,^[1] and
• Macrophage migration inhibitory factor.^[1]

References

1. Shen L, Hu J, Lu H, Wu M, Qin W, Wan D, Li YY, Gu J (Apr 2003). "The apoptosis-associated protein BNIPL interacts with two cell proliferation-related proteins, MIF and GFER". FEBS Letters 540 (1-3): 86–90. doi:10.1016/S0014-5793(03)00229-1. PMID 12681488.
2. Zhou YT, Soh UJ, Shang X, Guy GR, Low BC (Mar 2002). "The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequence". The Journal of Biological Chemistry 277 (9): 7483–92. doi:10.1074/jbc.M109459200. PMID 11741952.
3. "Entrez Gene: BNIPL BCL2/adenovirus E1B 19kD interacting protein like".
4. Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (Aug 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochemical and Biophysical Research Communications 308 (2): 379–85. doi:10.1016/s0006-291x(03)01387-1. PMID 12901880.
5. Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (Feb 1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Research 59 (3): 533–7. PMID 9973195.

Further reading

• Qin W, Hu J, Guo M, Xu J, Li J, Yao G, Zhou X, Jiang H, Zhang P, Shen L, Wan D, Gu J (Aug 2003). "BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis". Biochemical and Biophysical Research Communications 308 (2): 379–85. doi:10.1016/S0006-291X(03)01387-1. PMID 12901880.
• Xie L, Qin WX, He XH, Shu HQ, Yao GF, Wan DF, Gu JR (May 2004). "Differential gene expression in human hepatocellular carcinoma Hep3B cells induced by apoptosis-related gene BNIPL-2". World Journal of Gastroenterology 10 (9): 1286–91. PMID 15112343.
• Xie L, Qin WX, Li JJ, He XH, Shu HQ, Yao GF, Wan DF, Gu JR (Sep 2005). "cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1". Acta Biochimica et Biophysica Sinica 37 (9): 618–24. doi:10.1111/j.1745-7270.2005.00086.x. PMID 16143817.
• Valencia CA, Cotten SW, Liu R (Dec 2007). "Cleavage of BNIP-2 and BNIP-XL by caspases". Biochemical and Biophysical Research Communications 364 (3): 495–501. doi:10.1016/j.bbrc.2007.10.018. PMID 17961507.