BRD7

Bromodomain containing 7
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2I7K​
Identifiers
Symbols	BRD7 ; BP75; CELTIX1; NAG4
External IDs	MGI: 1349766 HomoloGene: 8085 IUPHAR: 2726 GeneCards: BRD7 Gene
Gene ontology Molecular function • p53 binding • transcription coactivator activity • transcription corepressor activity • protein binding • transcription factor binding • histone binding • transcription regulatory region DNA binding • lysine-acetylated histone binding Cellular component • nucleus • cytoplasm • BAF-type complex Biological process • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • cell cycle • negative regulation of cell proliferation • Wnt signaling pathway • positive regulation of histone acetylation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • negative regulation of G1/S transition of mitotic cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29117	26992
Ensembl	ENSG00000166164	ENSMUSG00000031660
UniProt	Q9NPI1	O88665
RefSeq (mRNA)	NM_001173984	NM_012047
RefSeq (protein)	NP_001167455	NP_036177
Location (UCSC)	Chr 16: 50.31 – 50.37 Mb	Chr 8: 88.33 – 88.36 Mb
PubMed search

Bromodomain-containing protein 7 is a protein that in humans is encoded by the BRD7 gene.^[1][2][3]

Interactions

BRD7 has been shown to interact with IRF2^[4] and HNRPUL1.^[5]

References

1. Cuppen E, van Ham M, Pepers B, Wieringa B, Hendriks W (November 1999). "Identification and molecular characterization of BP75, a novel bromodomain-containing protein". FEBS Lett 459 (3): 291–298. doi:10.1016/S0014-5793(99)01191-6. PMID 10526152.
2. Kaeser MD, Aslanian A, Dong MQ, Yates JR 3rd, Emerson BM (November 2008). "BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells". J Biol Chem 283 (47): 32254–32263. doi:10.1074/jbc.M806061200. PMC 2583284. PMID 18809673.
3. "Entrez Gene: BRD7 bromodomain containing 7".
4. Staal, A; Enserink J M; Stein J L; Stein G S; van Wijnen A J (November 2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. (UNITED STATES) 185 (2): 269–279. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. ISSN 0021-9541. PMID 11025449.
5. Kzhyshkowska, Julia; Rusch Andre; Wolf Hans; Dobner Thomas (April 2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. (England) 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. ISSN 0264-6021. PMC 1223277. PMID 12489984.

Further reading

• Staal A, Enserink JM, Stein JL, et al. (2000). "Molecular characterization of celtix-1, a bromodomain protein interacting with the transcription factor interferon regulatory factor 2". J. Cell. Physiol. 185 (2): 269–279. doi:10.1002/1097-4652(200011)185:2<269::AID-JCP12>3.0.CO;2-L. PMID 11025449.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kzhyshkowska J, Rusch A, Wolf H, Dobner T (2003). "Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7". Biochem. J. 371 (Pt 2): 385–93. doi:10.1042/BJ20021281. PMC 1223277. PMID 12489984.
• Zhou M, Peng C, Nie XM, et al. (2003). "[Expression of BRD7-interacting proteins,BRD2 and BRD3, in nasopharyngeal carcinoma tissues]". Ai Zheng 22 (2): 123–7. PMID 12600283.
• Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588–2596. doi:10.1167/iovs.02-1099. PMID 12766061.
• Zhang XM, Wang XY, Sheng SR, et al. (2003). "Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer". World J. Gastroenterol. 9 (8): 1729–33. PMID 12918109.
• Kim S, Lee J, Park J, Chung J (2003). "BP75, bromodomain-containing M(r) 75,000 protein, binds dishevelled-1 and enhances Wnt signaling by inactivating glycogen synthase kinase-3 beta". Cancer Res. 63 (16): 4792–5. PMID 12941796.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Zhou J, Ma J, Zhang BC, et al. (2004). "BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways". J. Cell. Physiol. 200 (1): 89–98. doi:10.1002/jcp.20013. PMID 15137061.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell 15 (6): 853–865. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Peng C, Zhou J, Liu HY, et al. (2006). "The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain". J. Cell. Biochem. 97 (4): 882–892. doi:10.1002/jcb.20645. PMID 16265664.
• Zhou M, Liu H, Xu X, et al. (2006). "Identification of nuclear localization signal that governs nuclear import of BRD7 and its essential roles in inhibiting cell cycle progression". J. Cell. Biochem. 98 (4): 920–930. doi:10.1002/jcb.20788. PMID 16475162.
• Zhou M, Xu XJ, Zhou HD, et al. (2007). "BRD2 is one of BRD7-interacting proteins and its over-expression could initiate apoptosis". Mol. Cell. Biochem. 292 (1–2): 205–212. doi:10.1007/s11010-006-9233-4. PMID 16786191.
• Liu H, Peng C, Zhou M, et al. (2006). "Cloning and characterization of the BRD7 gene promoter". DNA Cell Biol. 25 (6): 346–358. doi:10.1089/dna.2006.25.346. PMID 16792505.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.