BRMS1

Breast cancer metastasis suppressor 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2XUS​, 4AUV​
Identifiers
Symbols	BRMS1 ; DKFZp564A063
External IDs	OMIM: 606259 MGI: 2388804 HomoloGene: 32260 GeneCards: BRMS1 Gene
Gene ontology Molecular function • histone deacetylase activity • protein binding • histone deacetylase binding • NF-kappaB binding Cellular component • nucleus • nucleoplasm • cytoplasm • Sin3-type complex Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • transcription, DNA-templated • apoptotic process • histone deacetylation • negative regulation of NF-kappaB transcription factor activity • negative regulation of transcription, DNA-templated • positive regulation of protein deacetylation • positive regulation of anoikis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25855	107392
Ensembl	ENSG00000174744	ENSMUSG00000080268
UniProt	Q9HCU9	Q99N20
RefSeq (mRNA)	NM_001024957	NM_134155
RefSeq (protein)	NP_001020128	NP_598916
Location (UCSC)	Chr 11: 66.34 – 66.35 Mb	Chr 19: 5.04 – 5.05 Mb
PubMed search

Breast cancer metastasis-suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.^[1][2]

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.^[3] The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.^[2]

References

1. Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Res 60 (11): 2764–9. PMID 10850410.
2. "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
3. Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene

Further reading

• Meehan WJ, Welch DR (2003). "Breast cancer metastasis suppressor 1: update.". Clin. Exp. Metastasis 20 (1): 45–50. doi:10.1023/A:1022542519586. PMID 12650606.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Samant RS, Debies MT, Shevde LA; et al. (2002). "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1).". Int. J. Cancer 97 (1): 15–20. doi:10.1002/ijc.1569. PMID 11774238.
• Shevde LA, Samant RS, Goldberg SF; et al. (2002). "Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1.". Exp. Cell Res. 273 (2): 229–39. doi:10.1006/excr.2001.5452. PMID 11822878.
• Janneau JL, Maldonado-Estrada J, Tachdjian G; et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells.". J. Clin. Endocrinol. Metab. 87 (11): 5336–9. doi:10.1210/jc.2002-021093. PMID 12414911.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Meehan WJ, Samant RS, Hopper JE; et al. (2004). "Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription". J. Biol. Chem. 279 (2): 1562–9. doi:10.1074/jbc.M307969200. PMID 14581478.
• Cicek M, Samant RS, Kinter M; et al. (2004). "Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells". Clin. Exp. Metastasis 21 (2): 149–57. doi:10.1023/B:CLIN.0000024729.19084.f0. PMID 15168732.
• Nikolaev AY, Papanikolaou NA, Li M; et al. (2004). "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex". Biochem. Biophys. Res. Commun. 323 (4): 1216–22. doi:10.1016/j.bbrc.2004.08.227. PMID 15451426.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Stark AM, Tongers K, Maass N; et al. (2005). "Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases". J. Cancer Res. Clin. Oncol. 131 (3): 191–8. doi:10.1007/s00432-004-0629-9. PMID 15592684.
• DeWald DB, Torabinejad J, Samant RS; et al. (2005). "Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells". Cancer Res. 65 (3): 713–7. PMID 15705865.
• Cicek M, Fukuyama R, Welch DR; et al. (2005). "Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity". Cancer Res. 65 (9): 3586–95. doi:10.1158/0008-5472.CAN-04-3139. PMID 15867352.
• Hurst DR, Mehta A, Moore BP; et al. (2006). "Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone". Biochem. Biophys. Res. Commun. 348 (4): 1429–35. doi:10.1016/j.bbrc.2006.08.005. PMC 1557677. PMID 16919237.
• Samant RS, Clark DW, Fillmore RA; et al. (2007). "Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation". Mol. Cancer 6: 6. doi:10.1186/1476-4598-6-6. PMC 1796551. PMID 17227585.
• Rivera J, Megias D, Bravo J (2007). "Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1". J. Proteome Res. 6 (10): 4006–18. doi:10.1021/pr0703167. PMID 17854218.