CUGBP Elav-like family member 4

CUGBP, Elav-like family member 4
PDB rendering based on 2dgp.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DGP​, 2DNK​
Identifiers
Symbols	CELF4 ; BRUNOL-4; BRUNOL4
External IDs	OMIM: 612679 MGI: 1932407 HomoloGene: 23202 GeneCards: CELF4 Gene
Gene ontology Molecular function • nucleotide binding • translation repressor activity, nucleic acid binding • mRNA binding • BRE binding Cellular component • nucleus • cytoplasm Biological process • alternative mRNA splicing, via spliceosome • regulation of alternative mRNA splicing, via spliceosome • mRNA splice site selection • germ cell development • embryo development • negative regulation of translation • negative regulation of mRNA splicing, via spliceosome • positive regulation of mRNA splicing, via spliceosome • negative regulation of excitatory postsynaptic potential Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56853	108013
Ensembl	ENSG00000101489	ENSMUSG00000024268
UniProt	Q9BZC1	Q7TSY6
RefSeq (mRNA)	NM_001025087	NM_001146292
RefSeq (protein)	NP_001020258	NP_001139764
Location (UCSC)	Chr 18: 37.24 – 37.57 Mb	Chr 18: 25.48 – 25.75 Mb
PubMed search

CUGBP Elav-like family member 4 (CELF4) also known as bruno-like protein 4 (BRUNOL4) is a protein that in humans is encoded by the CELF4 gene.^[1][2]

Function

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Several transcript variants encoding different isoforms have been found for this gene, but their full-length nature has not been determined yet.^[2]

References

1. Good PJ, Chen Q, Warner SJ, Herring DC (Oct 2000). "A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator". J Biol Chem 275 (37): 28583–92. doi:10.1074/jbc.M003083200. PMID 10893231.
2. "Entrez Gene: BRUNOL4 bruno-like 4, RNA binding protein (Drosophila)".

Further reading

• Szafranski K, Schindler S, Taudien S; et al. (2008). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.". Genome Biol. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
• Han J, Cooper TA (2005). "Identification of CELF splicing activation and repression domains in vivo.". Nucleic Acids Res. 33 (9): 2769–80. doi:10.1093/nar/gki561. PMC 1126903. PMID 15894795.
• Singh G, Charlet-B N, Han J, Cooper TA (2004). "ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.". Nucleic Acids Res. 32 (3): 1232–41. doi:10.1093/nar/gkh275. PMC 373409. PMID 14973222.
• Tchernev VT, Mansfield TA, Giot L; et al. (2002). "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.". Mol. Med. 8 (1): 56–64. PMC 2039936. PMID 11984006.
• Ladd AN, Charlet N, Cooper TA (2001). "The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.". Mol. Cell. Biol. 21 (4): 1285–96. doi:10.1128/MCB.21.4.1285-1296.2001. PMC 99581. PMID 11158314.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.