Bromodomain and WD repeat-containing protein 1

Bromodomain and WD repeat domain containing 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BRWD1 ; C21orf107; N143; WDR9
External IDs MGI: 1890651 HomoloGene: 23130 GeneCards: BRWD1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 54014 93871
Ensembl ENSG00000185658 ENSMUSG00000022914
UniProt Q9NSI6 Q921C3
RefSeq (mRNA) NM_001007246 NM_001103179
RefSeq (protein) NP_001007247 NP_001096649
Location (UCSC) Chr 21:
39.18 – 39.32 Mb		 Chr 16:
95.99 – 96.08 Mb
PubMed search

Bromodomain and WD repeat-containing protein 1 (BRWD1) also known as WD repeat-containing protein 9 (WDR9) is a protein that in humans is encoded by the BRWD1 gene.[1]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats, and the function of this protein is not known. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates 3 transcript variants diverging at the 3' ends.[1]

References

  1. 1 2 "Entrez Gene: BRWD1 bromodomain and WD repeat domain containing 1".

Further reading

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