BTF3

Basic transcription factor 3
Rendering based on PDB 3LKX​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3LKX​, 3MCB​
Identifiers
Symbols	BTF3 ; BETA-NAC; BTF3a; BTF3b; NACB
External IDs	OMIM: 602542 MGI: 1202875 HomoloGene: 37453 GeneCards: BTF3 Gene
Gene ontology Molecular function • protein binding • poly(A) RNA binding Cellular component • nucleus • cytoplasm Biological process • in utero embryonic development • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • protein transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	689	218490
Ensembl	ENSG00000145741	ENSMUSG00000021660
UniProt	P20290	Q64152
RefSeq (mRNA)	NM_001037637	NM_001170540
RefSeq (protein)	NP_001032726	NP_001164011
Location (UCSC)	Chr 5: 73.5 – 73.51 Mb	Chr 13: 98.31 – 98.32 Mb
PubMed search

Transcription factor BTF3 is a protein that in humans is encoded by the BTF3 gene.^[1][2][3][4]

Function

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes.^[4]

Interactions

BTF3 has been shown to interact with CSNK2B.^[5]

References

1. Zheng XM, Black D, Chambon P, Egly JM (May 1990). "Sequencing and expression of complementary DNA for the general transcription factor BTF3". Nature 344 (6266): 556–9. doi:10.1038/344556a0. PMID 2320128.
2. Kanno M, Chalut C, Egly JM (Sep 1992). "Genomic structure of the putative BTF3 transcription factor". Gene 117 (2): 219–28. doi:10.1016/0378-1119(92)90732-5. PMID 1386332.
3. Freire MA (Apr 2005). "Translation initiation factor (iso) 4E interacts with BTF3, the beta subunit of the nascent polypeptide-associated complex". Gene 345 (2): 271–7. doi:10.1016/j.gene.2004.11.030. PMID 15716105.
4. "Entrez Gene: BTF3 basic transcription factor 3".
5. Grein S, Pyerin W (Jan 1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400.

Further reading

• Wiedmann B, Sakai H, Davis TA, Wiedmann M (1994). "A protein complex required for signal-sequence-specific sorting and translocation". Nature 370 (6489): 434–40. doi:10.1038/370434a0. PMID 8047162.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Grein S, Pyerin W (1999). "BTF3 is a potential new substrate of protein kinase CK2". Mol. Cell. Biochem. 191 (1–2): 121–8. doi:10.1023/A:1006806226764. PMID 10094400.
• Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
• Kusumawidjaja G, Kayed H, Giese N, Bauer A, Erkan M, Giese T, Hoheise JD, Friess H, Kleeff J (2007). "Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells". Cancer Biol. Ther. 6 (3): 367–76. doi:10.4161/cbt.6.3.3704. PMID 17312387.
• Symes AJ, Eilertsen M, Millar M, Nariculam J, Freeman A, Notara M, Feneley MR, Patel HR, Patel HR, Masters JR, Ahmed A (2013). "Quantitative Analysis of BTF3, HINT1, NDRG1 and ODC1 Protein Over-Expression in Human Prostate Cancer Tissue". PLoS ONE 8 (12): e84295. doi:10.1371/journal.pone.0084295. PMC 3874000. PMID 24386364.