BTG4
| B-cell translocation gene 4 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | BTG4 ; PC3B | ||||||||||
| External IDs | OMIM: 605673 MGI: 1860140 HomoloGene: 9734 GeneCards: BTG4 Gene | ||||||||||
| |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 54766 | 56057 | |||||||||
| Ensembl | ENSG00000137707 | ENSMUSG00000032056 | |||||||||
| UniProt | Q9NY30 | O70552 | |||||||||
| RefSeq (mRNA) | NM_017589 | NM_019493 | |||||||||
| RefSeq (protein) | NP_060059 | NP_062366 | |||||||||
| Location (UCSC) |
Chr 11: 111.47 – 111.51 Mb |
Chr 9: 51.12 – 51.12 Mb | |||||||||
| PubMed search | |||||||||||
Protein BTG4 also known as BTG family member 4 is a protein that in humans is encoded by the BTG4 gene (B-cell translocation gene 4).[1][2] BTG4 has anti-proliferative properties and can induce G1 cell cycle arrest.[2]
References
- ↑ "Entrez Gene: B-cell translocation gene 4".
- 1 2 Buanne P, Corrente G, Micheli L, Palena A, Lavia P, Spadafora C, Lakshmana MK, Rinaldi A, Banfi S, Quarto M, Bulfone A, Tirone F (September 2000). "Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium". Genomics 68 (3): 253–63. doi:10.1006/geno.2000.6288. PMID 10995567.
Further reading
- Auer RL, Starczynski J, McElwaine S; et al. (2005). "Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia.". Genes Chromosomes Cancer 43 (1): 1–10. doi:10.1002/gcc.20159. PMID 15672409.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Dong W, Tu S, Xie J; et al. (2009). "Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer.". Biochem. Biophys. Res. Commun. 387 (1): 132–8. doi:10.1016/j.bbrc.2009.06.140. PMID 19576178.
- Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMID 11429045.
- Toyota M, Suzuki H, Sasaki Y; et al. (2008). "Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.". Cancer Res. 68 (11): 4123–32. doi:10.1158/0008-5472.CAN-08-0325. PMID 18519671.
- Tirone F (2001). "The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair?". J. Cell. Physiol. 187 (2): 155–65. doi:10.1002/jcp.1062. PMID 11267995.
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