BYSL

Bystin-like
Identifiers
Symbols	BYSL ; BYSTIN
External IDs	OMIM: 603871 MGI: 1858419 HomoloGene: 2991 GeneCards: BYSL Gene
Gene ontology Molecular function • protein binding • poly(A) RNA binding Cellular component • nucleus • nucleolus • cytoplasm • cytoplasmic microtubule • membrane • cell projection • intracellular membrane-bounded organelle • apical part of cell • perinuclear region of cytoplasm Biological process • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • trophectodermal cell differentiation • cell adhesion • brain development • female pregnancy • cell proliferation • neuron differentiation • cellular response to lipopolysaccharide • cellular response to interleukin-1 • cellular response to growth factor stimulus • cellular response to organic cyclic compound Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	705	53414
Ensembl	ENSG00000112578	ENSMUSG00000023988
UniProt	Q13895	O54825
RefSeq (mRNA)	NM_004053	NM_016859
RefSeq (protein)	NP_004044	NP_058555
Location (UCSC)	Chr 6: 41.92 – 41.93 Mb	Chr 17: 47.6 – 47.61 Mb
PubMed search

Bystin is a protein that in humans is encoded by the BYSL gene.^[1][2][3]

Function

Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi.^[3]

Interactions

BYSL has been shown to interact with TROAP.^[4]

References

1. Pack SD, Pak E, Tanigami A, Ledbetter DH, Fukuda MN (Mar 1999). "Assignment1 of the bystin gene BYSL to human chromosome band 6p21.1 by in situ hybridization". Cytogenet Cell Genet 83 (1–2): 76–7. doi:10.1159/000015131. PMID 9925933.
2. Miyoshi M, Okajima T, Matsuda T, Fukuda MN, Nadano D (May 2007). "Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis". Biochem J 404 (3): 373–81. doi:10.1042/BJ20061597. PMC 1896285. PMID 17381424.
3. "Entrez Gene: BYSL bystin-like".
4. Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN (Apr 1998). "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5027–32. doi:10.1073/pnas.95.9.5027. PMC 20207. PMID 9560222.

Further reading

• Suzuki N, Zara J, Sato T, Ong E, Bakhiet N, Oshima RG, Watson KL, Fukuda MN (1998). "A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells.". Proc. Natl. Acad. Sci. U.S.A. 95 (9): 5027–32. doi:10.1073/pnas.95.9.5027. PMC 20207. PMID 9560222.
• Suzuki N, Nakayama J, Shih IM, Aoki D, Nozawa S, Fukuda MN (1999). "Expression of trophinin, tastin, and bystin by trophoblast and endometrial cells in human placenta.". Biol. Reprod. 60 (3): 621–7. doi:10.1095/biolreprod60.3.621. PMID 10026108.
• Nakayama J, Aoki D, Suga T, Akama TO, Ishizone S, Yamaguchi H, Imakawa K, Nadano D, Fazleabas AT, Katsuyama T, Nozawa S, Fukuda MN (2004). "Implantation-dependent expression of trophinin by maternal fallopian tube epithelia during tubal pregnancies: possible role of human chorionic gonadotrophin on ectopic pregnancy.". Am. J. Pathol. 163 (6): 2211–9. doi:10.1016/S0002-9440(10)63579-1. PMC 1892375. PMID 14633596.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.