Bacillus spore morphogenesis and germination holin family

The Bacillus Spore Morphogenesis and Germination Holin (BSH) Family (TC# 1.E.23) is a family of proteins named after a holin in Bacillus subtilis described to be involved in spore morphogenesis and germination by Real et al (2005). The gene encoding this holin is ywcE. Mutants lacking this gene or it's product have spores that exhibit outer coat defects. These spores lack the characteristic striatal pattern resulting in the failure of the outer coat to attach to the underlying inner coat. Finally, the mutant spores accumulate reduced amounts of dipicolinic acid.^[1] BSH proteins average about 90 amino acyl residues in length and exhibit 3 transmembrane segments (TMSs). A representative list of homologous proteins proteins, found only in Bacillus species, is available in the Transporter Classification Database.^[2]

See also

• Holin
• Lysin
• Transporter Classification Database

Further reading

• Reddy, Bhaskara L.; Saier Jr., Milton H. (2013-11-01). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochimica et Biophysica Acta (BBA) - Biomembranes 1828 (11): 2654–2671.doi:10.1016/j.bbamem.2013.07.004. PMC 3788059.PMID 23856191.
• Saier, Milton H.; Reddy, Bhaskara L. (2015-01-01). "Holins in Bacteria, Eukaryotes, and Archaea: Multifunctional Xenologues with Potential Biotechnological and Biomedical Applications". Journal of Bacteriology 197(1): 7–17. doi:10.1128/JB.02046-14. ISSN 0021-9193.PMC 4288690. PMID 25157079.

References

1. Real, Gonçalo; Pinto, Sérgio M.; Schyns, Ghislain; Costa, Teresa; Henriques, Adriano O.; Moran, Charles P. (2005-09-01). "A gene encoding a holin-like protein involved in spore morphogenesis and spore germination in Bacillus subtilis". Journal of Bacteriology 187 (18): 6443–6453. doi:10.1128/JB.187.18.6443-6453.2005. ISSN 0021-9193. PMC 1236627. PMID 16159778.
2. "1.E.23 The Bacillus Spore Morphogenesis and Germination Holin (BSH) Family". Transporter Classification Database. Retrieved 2016-03-28.

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