Bacoside A

Chemical structure of bacoside A3, a major constituent of bacoside A

Bacoside A is a mixture of chemical compounds, known as bacosides, isolated from Bacopa monnieri.^[1] Its major constituents include the saponins bacoside A3, bacopaside II, jujubogenin isomer of bacopasaponin C, and bacopasaponin C.^[2][3] The mixture has been studied in in vitro experiments and animal models for its potential neuroprotectivity.^{[4][5][6][7][8][9][10][11]}

References

1. Majumdar; et al. (2013). "Bacosides and Neuroprotection". Natural Products: 3639–3660. doi:10.1007/978-3-642-22144-6_157.
2. M. Deepak, G. K. Sangli, P. C. Arun and A. Amit (January–February 2005). "Quantitative determination of the major saponin mixture bacoside A in Bacopa monnieri by HPLC". Phytochemical Analysis 16 (1): 24–29. doi:10.1002/pca.805.
3. "Bacoside A, mixture of Bacoside A3, Bacopaside II, Bacopaside X and Bacopasaponin C". Sigma-Aldrich.
4. Thomas, RB; Joy, S; Ajayan, MS; Paulose, CS (2013). "Neuroprotective Potential of Bacopa monnieri and Bacoside a Against Dopamine Receptor Dysfunction in the Cerebral Cortex of Neonatal Hypoglycaemic Rats". Cellular and molecular neurobiology 33 (8): 1065–74. doi:10.1007/s10571-013-9973-0. PMID 23975094.
5. Russo; Borrelli (2005). "Bacopa monniera, a reputed nootropic plant: an overview". Phytomedicine 12: 305–317. doi:10.1016/j.phymed.2003.12.008. PMID 15898709.
6. Aguiar and Borowski, 2013. Neuropharmacological Review of the Nootropic Herb Bacopa monnieri. Rejuvenation Research. http://online.liebertpub.com/doi/abs/10.1089/rej.2013.1431
7. Bhattacharya, SK; Bhattacharya, A; Kumar, A; Ghosal, S (2000). "Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus". Phytother Res 14: 174–179. doi:10.1002/(sici)1099-1573(200005)14:3<174::aid-ptr624>3.0.co;2-o.
8. Anbarasi, K; Vani, G; Balakrishna, K; Devi, CS (2006). "Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats". Life Sci 78: 1378–1384. doi:10.1016/j.lfs.2005.07.030. PMID 16226278.
9. Anbarasi, K; Sabitha, KE; Devi, CS (2005). "Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of bacoside A.". Environ Toxicol Pharmacol 20: 345–350. doi:10.1016/j.etap.2005.03.006.
10. Vohora, D; Pal, SN; Pillai, KK (2000). "Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant". J Ethnopharmacol 71: 383–390. doi:10.1016/s0378-8741(99)00213-5.
11. Hota, SK; Barhwal, K; Baitharu, I; Prasad, D; Singh, SB; Ilavazhagan, G (2009). "Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment". Neurobiol Dis 34: 23–39. doi:10.1016/j.nbd.2008.12.006.