Barakol

Barakol

Systematic (IUPAC) name
2,5-Dimethyl-3aH-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol
Identifiers
CAS Number	24506-68-1
ATC code	none
PubChem	CID 3080731
ChemSpider	2338470
Chemical data
Formula	C13H12O4
Molar mass	232.231 g/mol
SMILES CC2=Cc3cc(O)cc(c13)OC(C)=CC1(O)O2
InChI InChI=1S/C13H12O4/c1-7-3-9-4-10(14)5-11-12(9)13(15,17-7)6-8(2)16-11/h3-6,14-15H,1-2H3 Key:LVPNMZHEDIKUFK-UHFFFAOYSA-N
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Barakol is a compound found in the plant Senna siamea,^[1] which is used in traditional herbal medicine. It has sedative and anxiolytic effects,^[2][3] but use for these purposes is now discouraged due to hepatotoxicity.^[4]

References

1. Padumanonda, T.; Gritsanapan, W. (March 2006). "Barakol Contents in Fresh and Cooked Senna siamea Leaves". The Southeast Asian Journal of Tropical Medicine and Public Health 37 (2): 388–393. PMID 17125004.
2. Thongsaard, W.; Pongsakorn, S.; Sudsuang, R.; Bennett, G. W.; Kendall, D. A.; Marsden, C. A. (January 1997). "Barakol, a Natural Anxiolytic, Inhibits Striatal Dopamine Release but Not Uptake in vitro". European Journal of Pharmacology 319 (2-3): 157–164. doi:10.1016/S0014-2999(96)00850-3. PMID 9042586.
3. Sukma, M.; Chaichantipyuth, C.; Murakami, Y.; Tohda, M.; Matsumoto, K.; Watanabe, H. (November 2002). "CNS Inhibitory Effects of Barakol, a Constituent of Cassia siamia Lamk". Journal of Ethnopharmacology 83 (1-2): 87–94. doi:10.1016/S0378-8741(02)00206-4. PMID 12413711.
4. Hongsirinirachorn, M.; Threeprasertsuk, S.; Chutaputti, A. (June 2003). "Acute Hepatitis Associated with Barakol". Journal of the Medical Association of Thailand = Chotmaihet Thangphaet. 86 Suppl. 2: S484–489. PMID 12930029.